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Glossary Secondary Hair Germ

cluster of cells initiating new hair growth cycle

The Secondary Hair Germ is a cluster of cells located at the base of the hair follicle, which plays a crucial role in the regeneration of hair during the hair growth cycle. These cells become active during the transition from the resting phase (telogen) to the growth phase (anagen), helping to initiate the formation of a new hair shaft.

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Research

5 / 1000+ results

research Ber‐EP4 antigen is a marker for a cell population related to the secondary hair germ

21 citations , June 2004 in “Experimental Dermatology”

This study found that Ber-EP4 immunoreactivity is present in specific areas of hair follicles across different stages of the hair cycle, particularly in the secondary hair germ, but not in mature anagen follicles.

research 1017 The prostaglandin F2α analog bimatoprost activates secondary hair germ cells to promote hair growth through two distinct signaling pathways

July 2026 in “Journal of Investigative Dermatology”

This study uncovered that bimatoprost, a prostaglandin analog, promotes hair growth by activating hair follicle progenitor cells through two pathways: the PTGFR-MAPK signaling axis and an unexpected IGF1R-PCAD-AKT signaling axis, suggesting new potential targets for treating hair disorders.

Central Precocious Puberty Secondary to Peripheral Precocious Puberty Due to a Pineal Germ Cell Tumor: A Case and Review of Literature

research Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature

October 2023 in “BMC endocrine disorders”

In this case study, researchers observed a 5.8-year-old male with peripheral precocious puberty due to a germ cell tumor, marked by elevated human chorionic gonadotropin levels. Treatment normalized hormone levels and arrested the puberty progression, highlighting melatonin's potential role in transitions to central precocious puberty.

research PA11 A rare case of a severe papulopustular dermatosis secondary to a germline EGFR mutation

June 2026 in “British Journal of Dermatology”

In this case report, researchers observed a Slovakian neonate with a rare EGFR genetic mutation who presented with severe neonatal dermatoses, ichthyosis, and multisystem complications, emphasizing the significance of genetic diagnosis for such complex conditions.

research Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

40 citations , November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that different melanocyte subpopulations in hair follicles have varying patterns of apoptosis and survival during the catagen phase, which may inform models for modulating melanocyte behavior in vivo.

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Learn

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learn wheat germ

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community Minoxidil is highly toxic to pets — help push for proper labeling [Petition]

in Minoxidil 251 upvotes 1 year ago

Minoxidil is highly toxic to pets, particularly cats and dogs, and there is a call for proper labeling to warn pet owners. Despite some skepticism about the effectiveness of petitions, many agree that awareness and caution are necessary to prevent accidental poisoning.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community Dermatologist says finasteride is no longer prescribed after apothecaries warning (Austria)

65 upvotes 8 months ago

In Austria, finasteride prescriptions are restricted due to suicide risk concerns, with new prescriptions only for current users. Alternatives like topical finasteride, dutasteride, and online purchases face legal challenges.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

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Experts

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