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Glossary Secondary Hair Germ

cluster of cells initiating new hair growth cycle

The Secondary Hair Germ is a cluster of cells located at the base of the hair follicle, which plays a crucial role in the regeneration of hair during the hair growth cycle. These cells become active during the transition from the resting phase (telogen) to the growth phase (anagen), helping to initiate the formation of a new hair shaft.

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community Minoxidil is highly toxic to pets — help push for proper labeling [Petition]

in Minoxidil 251 upvotes 1 year ago

Minoxidil is highly toxic to pets, particularly cats and dogs, and there is a call for proper labeling to warn pet owners. Despite some skepticism about the effectiveness of petitions, many agree that awareness and caution are necessary to prevent accidental poisoning.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community Dermatologist says finasteride is no longer prescribed after apothecaries warning (Austria)

65 upvotes 8 months ago

In Austria, finasteride prescriptions are restricted due to suicide risk concerns, with new prescriptions only for current users. Alternatives like topical finasteride, dutasteride, and online purchases face legal challenges.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

community Federal Grant Cuts have impacted PP405 related research

459 upvotes 1 year ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community Warning: Minoxidil usage around pets

in Minoxidil 454 upvotes 1 year ago

Minoxidil is highly toxic to pets, especially cats and dogs, even in small amounts. Many users have switched to oral minoxidil to prevent accidental exposure to their pets.

community People's ignorance on MPB is both frustrating and harmful to balding men and it's important to educate other balding men on Fin/Min/Dut (Discussion)

156 upvotes 1 year ago

Many are unaware of effective male pattern baldness treatments like finasteride and minoxidil, often opting for ineffective remedies. Educating others on proven treatments and potential side effects is crucial.

community How much difference hair fibers and mousse make

in Styling 1459 upvotes 1 year ago

The user applies Rogaine foam, Toppik hair fibers, and Tresemme mousse to improve hair appearance and has restarted finasteride after a year off. They are considering a hair transplant and are working on self-esteem related to hair loss.

community Secondary shedding, 6 months into oral minoxidil/finasteride 3mg chewables

55 upvotes 4 months ago

The user experienced significant hair regrowth and increased density after six months of using oral minoxidil and finasteride chewables, despite going through a secondary shedding phase. The only side effect mentioned was restlessness, and the user feels healthier overall.

community Could male-pattern baldness have a secondary photobiological function? The Solar Window Hypothesis

11 upvotes 2 weeks ago

Male-pattern baldness might increase UVB exposure on the scalp, potentially affecting vitamin D and skeletal health. The hypothesis is debated, with some seeing it as a minor benefit in specific contexts.

community Fin and Min shed after 9 months

70 upvotes 2 weeks ago

The user experienced significant hair improvement using oral finasteride and minoxidil but is now facing a secondary hair shedding phase after nine months, possibly linked to weight loss or seasonal changes. Despite concerns, others in the conversation suggest that such shedding is normal and temporary.

community Do you think most celebrities use Dutasteride instead of Finasteride?

in Finasteride/Dutasteride 58 upvotes 4 months ago

Celebrities may use Dutasteride for hair loss, but Finasteride is more commonly used due to its extensive research and long-term safety. Dutasteride is considered more effective but is often used off-label or as a secondary option.

community 7 months of regime minoxidil and finasteride!!

in Is this regrowth? 57 upvotes 5 months ago

The user has been using minoxidil 12.5% and finasteride 1mg for 7 months, experiencing significant hair regrowth. They are considering adding dutasteride and using a dermaroller for further improvement.

community 31M started 0.25mg Finasteride 1.5mg finasteride in mid January 2026

in Progress Pictures 11 upvotes 5 months ago

A 31-year-old male started using 1.25mg oral Minoxidil and 0.25mg Finasteride in January 2026 to address hair thinning. Users suggest increasing doses and considering additional treatments like topical Minoxidil, microneedling, or switching to dutasteride for better results.

community Low normal DHT but still losing the hairs from the front scalp. Looking for suggestions on what treatment can be used to treat hair loss ?

8 upvotes 2 years ago

A 31-year-old male with low normal-range testosterone and DHT is experiencing significant hair loss from the front scalp. He has tried Minoxidil, vitamin D3 and B12 supplements, and exercises regularly but is still seeking the root cause and effective treatment.

community Finasteride and male phenotypes

5 upvotes 11 years ago

Finasteride's effectiveness and side effects may vary based on male phenotypes, with some users noting differences in response related to body and facial hair characteristics. Some users report success with lower doses, while others experience side effects, suggesting individual variability in response to the treatment.

community 6 mois avant après minox + fin 1mg

in Progress Pictures 2 upvotes 4 weeks ago

The user has been using topical minoxidil for over two years and finasteride 1mg for six and a half months, noticing some progress without side effects. They mention initial concerns about side effects but attribute difficulties to lack of sleep and long work hours.

community Efficacy and Safety of Oral Dutasteride 0.5 mg Combined with Oral Minoxidil 2.5 mg for Male Androgenetic Alopecia: A Retrospective Cohort Study

93 upvotes 3 weeks ago

Oral dutasteride 0.5 mg combined with oral minoxidil 2.5 mg is highly effective for male androgenetic alopecia, showing over 60% improvement and 98% stabilization at 6 months, with low adverse event rates. Patients with severe baseline conditions respond better and faster to this treatment.

community Oral 1mg Finesteride 2mg Minoxidil

485 upvotes 3 months ago

The user experienced significant hair regrowth using 1mg finasteride and 2mg minoxidil daily, along with Nizoral shampoo and rosemary oil. They are curious about further improving hair density and whether increasing the minoxidil dose would help.

community Does This Invalidate PP405 Completely?

6 months ago

PP405's effectiveness in increasing hair density is questioned due to a small sample size, despite investment from Google Ventures. Users express skepticism and suggest waiting for more conclusive results.

community Crazy Hair Loss Reversal! 🏳️‍⚧️💖

in Transgender 1 year ago

Transgender hormone therapy, including Estradiol Valerate, Spironolactone, and Progesterone Micronized, can reverse male pattern baldness and improve hair health. The user shares their positive experience with hair regrowth after transitioning from male to female.

community What can be the real reason of Finasteride SE ?

18 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

community KX-826+Minoxidil Outperforms Minoxidil Alone for AGA Treatment: 30+ New Hairs/cm² (24 Weeks, P=0.0075)

38 upvotes 1 year ago

KX-826 combined with minoxidil significantly increases hair growth compared to minoxidil alone for treating male androgenetic alopecia, with no unexpected safety concerns. Users discuss various hair loss treatments, including KX-826, minoxidil, finasteride, and RU58841, sharing personal experiences and sourcing information.

community What is next for pp405 in phase 2b?

16 upvotes 1 year ago

PP405 is progressing to Phase 2b trials, with results expected in late 2025 or early 2026, and potential Phase 3 trials in 2026. Some users experienced side effects from finasteride and are hopeful for PP405 as an alternative treatment.

community Whats the goal pf Nizoral and Ketoconzole shampoos?

in Ketoconazole 9 upvotes 1 year ago

Ketoconazole shampoos are primarily for dandruff and fungus but may aid hair growth slightly, though results are minor compared to finasteride and minoxidil. Users report it helps with scalp health and inflammation, but it can dry out hair if used too often.

community Realistically, how much PP405 will cost?

33 upvotes 1 year ago

PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.

community Simple to add GHK-Cu to RU58841?

1 upvotes 1 year ago

The conversation is about a user seeking advice on adding GHK-Cu to RU58841 for hair loss treatment, while already using oral minoxidil, dutasteride, ketoconazole shampoo, and considering LLLT. They are unsure about the concentration and carrier solution for GHK-Cu.

community Is hydrocortisone that bad for your scalp?

1 upvotes 1 year ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.