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Ph-Responsive Hydrogel With Dual-Crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing

research pH-Responsive Hydrogel with Dual-crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing

January 2025 in “Regenerative Biomaterials”

In this study, a new pH-responsive hydrogel composed of polyvinyl alcohol and boric acid was found to release salvianolic acid B effectively, reducing excessive scar formation and enhancing tissue regeneration during early-stage wound healing.

research Combined AlloDerm® and thin skin grafting for the treatment of postburn dyspigmented scar contracture of the upper extremity

26 citations , February 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.

Controlled Release of the Alpha-Tocopherol-Derived Metabolite Alpha-13'-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

research Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

11 citations , July 2021 in “Nanomaterials”

This study found that α-13′-carboxychromanol significantly accelerated wound healing and improved tissue quality in a mouse model, especially when delivered with bacterial nanocellulose under diabetic conditions.

research An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing

January 2026 in “RSC Advances”

The hydrogel helps heal wounds without scars by releasing two drugs gradually.

research Nano drug delivery systems: a promising approach to scar prevention and treatment

15 citations , August 2023 in “Journal of Nanobiotechnology”

This review highlights recent advancements in using nanotechnology for scar prevention and treatment, emphasizing the unique properties of nanomaterials in drug delivery and the challenges that remain in maximizing their potential for effective scar interventions.

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Community Join

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community Anybody else obsessively searching for pp405 and counting the days?

69 upvotes 1 year ago

People are eagerly awaiting the release of PP405, a new hair loss treatment. Some are using minoxidil and finasteride in the meantime, but there are concerns about scams and unverified products.

community Can pp405 revive dead follicles for long time bald people? Are those even dead? After 10+ years bald

47 upvotes 1 year ago

PP405 may revive dormant hair follicles but is unlikely to help with long-term baldness where follicles are replaced by scar tissue. It is seen as a potential adjunct to treatments like minoxidil and finasteride, but its effectiveness on deeply fibrotic or scarred areas is doubtful.

community Verteporfin Update with Dr Blake Bloxham

28 upvotes 2 years ago

The conversation discusses Dr. Blake Bloxham's experiment with Verteporfin for hair loss, with one person suggesting more doctors should try it as it seems beneficial. Another comment notes that results at 4-5 months were not very impressive.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Are Minoxidil & Finasteride/Dutastide the only REAL things that work? Is there anything else I can do for diffuse thinning that actually works on top of these?

13 upvotes 1 year ago

Minoxidil and finasteride are the main effective treatments for hair loss. RU58841 is discussed as a potential option but has concerns about safety and side effects.

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Learn

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Overview

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

learn Scalp Micropigmentation

Will my scar completely disappear after scalp micropigmentation? Scalp micropigmentation camouflages scars but does not make them completely disappear.

learn Hair Transplant

Does FUT leave a scar and is it visible? FUT leaves a linear scar that may be visible with very short hairstyles.

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