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The Possible Implication of the S250C Variant of the Autoimmune Regulator Protein in a Patient with Autoimmunity and Immunodeficiency: In Silico Analysis Suggests a Molecular Pathogenic Mechanism for the Variant

research The possible implication of the S250C variant of the autoimmune regulator protein in a patient with autoimmunity and immunodeficiency: in silico analysis suggests a molecular pathogenic mechanism for the variant

11 citations , July 2014 in “Gene”

This study reports a unique case of common variable immunodeficiency with autoimmunity linked to a heterozygous S250C variant in the autoimmune regulator gene, suggesting a potential molecular basis for this combination.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.

research Looking westwards: Men in transnational men’s magazine advertising in India

2 citations , October 2017 in “Global Media and Communication”

In this study, ads in leading Indian men's magazines featured more international brands and Caucasian models, while promoting a class-based global masculinity among upper-class urban Indian men.

research Diagnostic approach to low‐renin hypertension

29 citations , May 2018 in “Clinical Endocrinology”

This review discusses the differential diagnosis of low-renin hypertension and highlights recent genetic discoveries related to familial forms, but it presents no new clinical results.

research Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype

February 2024 in “BMC genomics”

This study identified a gene variant in the TRPV3 gene that may explain the suri alpaca phenotype, characterized by longer and less crimped fleece, suggesting this variant's involvement in the development of these hair characteristics compared to the huacaya phenotype.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Dermatologist says you can’t prevent hair loss and medications don’t work

143 upvotes 11 months ago

Finasteride, dutasteride, and minoxidil can help prevent or slow hair loss for many, though results vary. The dermatologist's claim that no medication works is incorrect, as these treatments are effective for some individuals.

community This is what some balding dudes are like

in Satire 1047 upvotes 1 year ago

Some people avoid finasteride due to side effects but engage in unhealthy habits. Minoxidil and finasteride are common hair loss treatments, with varied side effect experiences.

community Young guys 18-25, did hair loss destroy you mentally and affect your life? And if you did recover from it have you truly ever felt the same?

in Chat 146 upvotes 11 months ago

Hair loss greatly affects mental health and social life for young men. Treatments like finasteride, minoxidil, and hair transplants are common, with mixed success and ongoing self-esteem challenges.

community Has been on minoxidil for 5 years. Microneedling for 4 weeks no results.

in Minoxidil 27 upvotes 1 year ago

The user has used minoxidil for five years and added microneedling for four weeks without seeing results. They are considering a hair transplant but are advised that hair loss will persist without a DHT blocker.

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