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community Research behind RU-58642? Has anyone heard of this?

in Research/Science 1 upvotes 1 year ago

RU-58642 is a powerful anti-androgen that was not developed further, possibly due to safety concerns or financial reasons. RU58841 is a topical alternative, but it is less effective than finasteride and dutasteride, and its long-term effects are not well-studied.

community RU and cetosomal minoxidil topical

1 upvotes 7 months ago

Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

community RU/Pyrilutamide access and purchase

3 upvotes 8 months ago

The conversation is about accessing and purchasing RU58841 or Pyrilutamide for hair loss treatment, with mentions of alternatives like Breezula. Users discuss price differences in various countries and suggest websites like rudirect.com for purchasing.

community RU-58441 Janoshik test result of Made-In-China Supplier

29 upvotes 9 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

community RU-58841 appears to not be soluble in common Minoxidil solutions

7 upvotes 11 months ago

RU-58841 does not dissolve well in common Minoxidil solutions due to water content, requiring a 70/30 ethanol/propylene glycol mix. Users report using separate solutions for RU-58841 and finasteride/Minoxidil for better results.

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Research

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Synthesis and Structure–Activity Studies of Side-Chain Derivatized Arylhydantoins for Investigation as Androgen Receptor Radioligands

research Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

18 citations , April 2001 in “Bioorganic & Medicinal Chemistry Letters”

This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.

research The significance of coronavirus infection in the development of reproductive and lower urinary tract lesions

3 citations , July 2021 in “Urology Herald”

This review discusses the impact of COVID-19 on genitourinary organs, highlights areas for further study, and reports no new clinical results; the authors suggest long-term analysis to clarify outcomes.

research Alternative synthesis of the anti-baldness compound RU58841

4 citations , January 2014 in “RSC Advances”

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations , February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

research Potential targets in the discovery of new hair growth promoters for androgenic alopecia

59 citations , May 2014 in “Expert Opinion on Therapeutic Targets”

This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.

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