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GlossaryRho kinase (Rho-associated protein kinase)

enzyme regulating cell shape and movement via the cytoskeleton

Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research Efficient Establishment of an Optimized Culture Condition for Cashmere Goat Primary Hair Follicle Stem Cells

January 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Adding Y-27632 and bFGF to the culture medium greatly improves goat hair follicle stem cell growth and quality.

research A Novel Immune Competent Murine Hypertrophic Scar Contracture Model: A Tool to Elucidate Disease Mechanism and Develop New Therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

The model helps understand scar contraction and develop new treatments.

research The Transmembrane Protein LRIG1 Regulates Receptor Tyrosine Kinases in Skin Development and Homeostasis

September 2017 in “Journal of Investigative Dermatology”

LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community This guy won the jackpot in the hair genetics lottery. He had to pay the taxes (white hair) though

in Chat 2073 upvotes 4 months ago

A man with thick, white hair is admired for his genetics, leading to discussions about hair loss and the preference for white hair over balding. Some speculate about the use of treatments like finasteride.