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GlossaryRho kinase (Rho-associated protein kinase)

enzyme regulating cell shape and movement via the cytoskeleton

Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

3 citations, May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research Efficient Establishment of an Optimized Culture Condition for Cashmere Goat Primary Hair Follicle Stem Cells

January 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Adding Y-27632 and bFGF to the culture medium greatly improves goat hair follicle stem cell growth and quality.

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

72 citations, November 2012 in “PloS one”

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

24 citations, December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.