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GlossaryROCK inhibitor (Rho kinase inhibitor)

blocks enzymes involved in cell contraction and motility

A ROCK inhibitor, also known as a Rho-associated kinase inhibitor, is a type of drug that blocks the activity of Rho-associated kinases (ROCKs). These enzymes play a crucial role in various cellular functions, including contraction, motility, proliferation, and apoptosis. By inhibiting ROCKs, these drugs can help treat conditions like hypertension, glaucoma, and even promote hair growth in cases of alopecia by improving blood flow and reducing inflammation.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

research Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

64 citations, August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

research Boosting and Rescuing Epidermal Superior Population from Fresh Keratinocyte Cultures

15 citations, August 2013 in “Stem Cells and Development”

The method increases stem-like cells for better skin regeneration.

research The Development of an In Vitro Human Hair Follicle Organoid With a Complexity Similar to That In Vivo

February 2024 in “Biomedical materials”

Scientists created a lab-grown hair follicle model that behaves like real hair and could improve hair loss treatment research.

research Enzymes

1 citations, November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.