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    Glossary Wnt signaling pathway

    regulates cell growth and differentiation, crucial for hair regeneration

    The Wnt signaling pathway is a complex network of proteins that play a crucial role in regulating cell growth, development, and differentiation. It is particularly important in the context of hair growth and regeneration, as it influences the activity of hair follicle stem cells. Dysregulation of this pathway can lead to conditions like alopecia or other hair growth disorders.

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    1. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding Nature · 2007 · 829 citations
    2. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice Genes & Development · 2008 · 556 citations
    3. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009 · 326 citations
    4. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Signal Transduction and Targeted Therapy · 2022 · 318 citations
    5. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis Development · 2004 · 293 citations
    6. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999 · 271 citations
    7. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011 · 260 citations
    8. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012 · 260 citations
    9. Human CD133 <sup>+</sup> Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling Circulation Research · 2009 · 245 citations
    10. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012 · 232 citations
    11. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    12. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex Nature · 2010 · 199 citations
    13. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    14. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators Nature Cell Biology · 2014 · 173 citations
    15. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012 · 170 citations
    16. Wnt signaling induces epithelial differentiation during cutaneous wound healing BMC Cell Biology · 2006 · 159 citations
    17. WNT Signaling in Disease Cells · 2019 · 144 citations
    18. Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities Pharmacology & Therapeutics · 2018 · 140 citations
    19. Hairless triggers reactivation of hair growth by promoting Wnt signaling Proceedings of the National Academy of Sciences of the United States of America · 2005 · 137 citations
    20. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    21. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors Proceedings of the National Academy of Sciences of the United States of America · 2014 · 130 citations
    22. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    23. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    24. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    25. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    26. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017 · 105 citations
    27. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway Journal of Cell Biology · 2014 · 103 citations
    28. Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway Nature Communications · 2011 · 101 citations
    29. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    30. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations