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Did you mean Vascular Endothelial Growth Factor Receptor 2?

Glossary Vascular Endothelial Growth Factor Receptor 2

regulates blood vessel formation by binding to VEGF

Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), also known as KDR, is a protein found on the surface of cells that plays a crucial role in the formation of blood vessels. It binds to VEGF (Vascular Endothelial Growth Factor), triggering a series of signals that promote the growth and maintenance of the vascular system, which is essential for supplying nutrients and oxygen to tissues. This receptor is particularly important in processes like wound healing and the growth of new blood vessels in tumors.

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research Use of natural molecules as anti-angiogenic inhibitors for vascular endothelial growth factor receptor

16 citations , December 2012 in “Bioinformation”

This study suggests that natural molecules like curcumin, EGCG, barringtozenol, and finasteride may be effective inhibitors for VEGFR, potentially offering a cancer chemoprevention alternative to pazopanib.

research Genetic effects of vascular endothelial growth factor and its receptor 2 on feather maturity in three chicken breeds

1 citations , January 2019 in “British Poultry Science”

This study found that specific genes related to vascular endothelial growth factors are critical for feather maturity in certain chicken breeds, identifying key genetic markers that could enhance breeding efficiency.

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

research Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

6 citations , March 2018 in “Journal of Medicinal Food”

This study demonstrated that water-soluble peptides from egg yolk, termed "hair growth peptide," stimulated human hair follicle cell growth and improved hair growth in female pattern hair loss.

research Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial growth factor secretion

30 citations , March 2008 in “Wound Repair and Regeneration”

This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.

research Role of vascular endothelial growth factor in hair follicle biology

January 2009 in “International Journal of Pathology and Clinical Medicine”

This article reviews the role of VEGF in hair follicle growth and cycle modulation but concludes that its specific molecular mechanisms in hair follicle growth remain unclear.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

research Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation

October 2024 in “Current Issues in Molecular Biology”

In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Regulation of microvascular permeability by vascular endothelial growth factors

48 citations , May 2002 in “Journal of Anatomy”

The researchers reported that VEGF increases vascular permeability in mesenteric microvessels of anaesthetized frogs through specific cellular pathways involving tyrosine autophosphorylation and PLC activation.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.

research Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines

March 2023 in “Journal of Applied Biomedicine”

This study suggests that oleanolic acid may promote hair growth in mice with testosterone-induced androgenetic alopecia by activating the Wnt/β-catenin pathway and influencing various molecular levels.

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

research Anti-PDGF receptor β antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells

17 citations , May 2015 in “Nanomedicine: Nanotechnology, Biology and Medicine”

This study found that lipid nanocarriers called squarticles, conjugated with an antibody, enhanced minoxidil uptake in dermal papilla cells, potentially improving alopecia treatments.

research Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model

11 citations , September 2012 in “Journal of Nanjing Medical University”

In this study, cyclosporine A stimulated hair growth in mouse vibrissae organ culture by promoting matrix cell proliferation and altering growth factor expression.

Efficacy of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract on Hair Growth and Anchorage in Human Dermal Papilla Cells

research 721 Efficacy of silybum marianum extract, manganese PCA and lespedeza capitata extract on hair growth and anchorage in human dermal papilla cells

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that combining Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help improve hair growth and anchorage by targeting specific signaling pathways in human dermal papilla cells.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that in vitro treatments with 5alpha-reductase inhibitors and androgen receptor antagonists strongly stimulate VEGF expression in dermal papilla cells.

research Hair Growth–Promoting Effects of Adiponectin In Vitro

22 citations , June 2012 in “Journal of Investigative Dermatology”

This study found that adiponectin promotes hair growth in cultured human hair follicles, suggesting its receptors could be a target for clinical hair growth strategies.

research Influence of interleukin‐1α on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells

14 citations , September 2006 in “Experimental Dermatology”

This study suggests that interleukin-1 α influences dermal papilla cell activity by modifying androgen receptor expression and increasing the secretion of several growth factors and cytokines.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations , September 2021 in “Current Issues in Molecular Biology”

This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.

research Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo

4 citations , December 2022 in “Cells”

This study found that fibroblast-engineered nanovesicles significantly enhanced proliferation and migration of dermal papilla cells and increased hair follicle shaft size in ex vivo organ cultures, suggesting potential as a treatment for alopecia.

Insights Gained from Chickens' Rapid Hair Development During Hatching Lead to Discovery of Hair Growth Peptide Derived from Egg Yolk

research 1303 Insights gained from a chickens rapid hair development during hatching lead to discovery of hair growth peptide derived from egg yolk

April 2018 in “Journal of Investigative Dermatology”

This study found that a water-soluble peptide from chicken egg yolk, named Hair Growth Peptide, improved hair growth in mice and female pattern hair loss through increased IGF-1 and VEGF production.

research Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

508 citations , June 2009 in “Current drug metabolism”

This review details the skin and hematological toxicities of tyrosine kinase inhibitors like erlotinib, gefitinib, and imatinib, and highlights ongoing concerns about cardiac toxicity, reporting no new clinical findings.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

research Novel Application of Layered Expression Scanning for Proteomic Profiling of Plucked Hair Follicles

7 citations , January 2005 in “Dermatology”

This study demonstrates that LES-hair can detect differential protein expression in specific regions of plucked hair follicles, suggesting its potential for research and clinical applications like monitoring treatment effects in alopecia and cancer therapies.

research VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

6 citations , March 2019 in “Medical science monitor basic research/Medical science monitor. Basic research”

This study found that phosphorylated VEGFR-2 is present in human scalp epidermal appendages and suggests it plays a role in their daily regulation.

research Axitinib-induced repigmentation of grey hair in a patient with metastatic renal cell carcinoma

June 2025 in “BMJ Case Reports”

In this case report, researchers observed hair repigmentation in a man with metastatic renal cell carcinoma during treatment with axitinib, marking the first documented instance of this effect with axitinib without the use of hair dyes or other medications.

research Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia

May 2025 in “Acta Biomaterialia”

This study developed microneedles combining insulin-like growth factor-1 and type XVII collagen, showing more effective hair regeneration and reduced inflammation compared to minoxidil in a mouse model of androgenetic alopecia.

Co-Expression Pattern of VEGFR-2 With Indicators Related to Proliferation, Apoptosis, and Differentiation of Anagen Hair Follicles

research The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles

January 2023 in “Open Life Sciences”

This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.

research Recurrent inverse necrotizing infundibular crystalline folliculitis

1 citations , April 2024 in “Journal of Cutaneous Pathology”

This article presents a case of spontaneous, recurrent necrotizing infundibular crystalline folliculitis in the inguinal region and suggests unknown etiology possibly linked to microbiome and sebaceous gland dysfunction.

research Adverse Hair Reactions to New Targeted Therapies for Cancer

1 citations , March 2019 in “Actas Dermo-Sifiliográficas”

This review discusses the adverse effects on hair associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for comprehensive documentation of these effects.