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    Glossary Tumor Necrosis Factor Alpha

    protein involved in inflammation and immune system regulation

    Tumor Necrosis Factor Alpha (TNF-α) is a protein produced by the immune system that plays a crucial role in inflammation and the body's response to infection. It helps regulate immune cells, but excessive production of TNF-α is associated with chronic inflammatory diseases like rheumatoid arthritis and psoriasis.

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    1. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    2. Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study Genetic Testing and Molecular Biomarkers · 2014 · 26 citations
    3. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    4. Alteration of serum and tissue tumor necrosis factor alpha levels: A possible mechanism of action of oral pulse steroids in the treatment of alopecia areata Journal of Cosmetic Dermatology · 2018 · 5 citations
    5. Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors Journal of clinical and investigative dermatology · 2014 · 2 citations
    6. Tumor necrosis factor-alpha inhibitor associated psoriasiform alopecia (drug-induced psoriasiform alopecia) Informa Healthcare eBooks · 2012 · 1 citations
    7. Intralesional methotrexate in patchy alopecia areata: trichoscopic evaluation and effect on lesional tumour necrosis factor alpha Journal of the Egyptian Womenʼs Dermatologic Society · 2026
    8. Estimation of Dehydroepiandrosterone (DHEA) and Tumor Necrosis Factor–Alpha (TNF-α) Levels Women Diagnosed with Polycystic Syndrome DS Reviews of Research in Life Sciences · 2025
    9. - Tumor necrosis factor-alpha inhibitor associated psoriasiform alopecia (drug-induced psoriasiform alopecia) CRC Press eBooks · 2012
    10. Tumor necrosis factor-alpha inhibitor associated psoriasiform alopecia (drug-induced psoriasiform alopecia) Informa Healthcare eBooks · 2012
    11. Alopecia induced by tumour necrosis factor-alpha antagonists: description of 52 cases and disproportionality analysis in a nationwide pharmacovigilance database Rheumatology · 2014 · 26 citations
    12. Alopecia secondary to anti-tumor necrosis factor-alpha therapy Anais Brasileiros de Dermatologia · 2015 · 42 citations
    13. Psoriatic Alopecia/Alopecia Areata‐Like Reactions Secondary to Anti‐Tumour Necrosis Factor‐Alpha Therapy Australasian Journal of Dermatology · 2025 · 1 citations
    14. Incidence of adverse cutaneous drug reactions in a Mexican sample: an exploratory study on their association to tumour necrosis factor alpha TNF2 allele Journal of the European Academy of Dermatology and Venereology · 2009 · 6 citations
    15. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    16. Tumor necrosis factor α inhibitor-induced alopecia in pediatric patients: a cohort of 20 patients and review of the literature Archives of Dermatological Research · 2025 · 3 citations
    17. Scarring Alopecia in Tumor Necrosis Factor-α Antagonists-Induced Scalp Psoriasis Journal of Psoriasis and Psoriatic Arthritis · 2023 · 2 citations
    18. Detection of Serum Levels of Interleukins-17, 21, 6 and Tumor Necrosis Factor-α in Patients with Patchy Alopecia Areata and Their Association with Disease Severity Diseases · 2025
    19. Supplementary material for: Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice Figshare · 2023
    20. Psoriatic Alopecia in a Patient With Crohn Disease: An Uncommon Manifestation of Tumor Necrosis Factor α Inhibitors Cutis · 2021
    21. Expression of transforming growth factor-β_1 and tumor necrosis factor-α in mice with radiationinduced pulmonary injury 2010
    22. Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice Skin Pharmacology and Physiology · 2023
    23. Alopesi areata hastalarında serum interferon-gama, tümör nekrozis faktör-alfa, interlökin-13, interlökin-17 ve transforming growth faktör-beta düzeylerinin değerlendirilmesi 2016
    24. Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata Archives of Dermatological Research · 1996 · 91 citations
    25. Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla Journal of Dermatological Science · 2011 · 23 citations
    26. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    27. <i>Pinus thunbergii</i> bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice Molecular Medicine Reports · 2022 · 5 citations
    28. Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors Marine drugs · 2023 · 2 citations
    29. Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin Papers on Anthropology · 2012 · 1 citations
    30. DHEA and TNF-α: Key Factors in Managing Polycystic Ovary Syndrome in Iraqi Females International Journal of Scientific Research in Biological Sciences · 2025