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Disrupting the Tsc2 gene in certain cells leads to thicker skin, larger hair, and changes in hair growth signaling, which can be partly reversed with specific treatment.

TSC2 is crucial for proper hair follicle development and patterning.

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

Researchers identified genes and proteins that may influence wool thickness in sheep.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

mTORC1 activity is important for hair growth and color, and targeting it could help treat hair loss and greying.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

A baby had a unique skin condition with a pale patch and surrounding dark hairs, not linked to other health issues.

Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

The plant hormone auxin activates the TOR pathway, affecting gene expression related to growth and cell size.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Skin problems can be signs of hormone-related disorders and recognizing them early is important for treatment.

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

High mTORC1 activity slows hair growth and causes it to lose color.

A special diet can significantly reduce skin problems in dogs.

Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.

Exosomes could be a promising way to help repair skin and treat skin disorders.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

FOL-005, a hair growth promoter, acts locally on mouse skin where injected and could be a promising hair loss treatment.

New cell-based therapies may improve hair loss treatments in the future.

The ingredients could help prevent hair loss by promoting hair growth and increasing VEGF secretion.

The anti-hair loss shampoo effectively promotes hair growth and improves hair quality.

The document concludes that an experimental drug may help wound healing in Epidermolysis Bullosa, links Hydroa vacciniforme to EBV, discusses diagnosing hair loss disorders, finds many children with eczema have allergies, reviews the safety of a skin medication in children, notes side effects of a Duchenne's treatment, and identifies a marker for pediatric mastocytosis.