Search

for
Search:

Did you mean Transforming Growth Factor Alpha?

Glossary Transforming Growth Factor Alpha

protein involved in cell growth and hair follicle regulation

Transforming Growth Factor Alpha (TGF-α) is a protein that plays a crucial role in cell growth, proliferation, and differentiation. It binds to the epidermal growth factor receptor (EGFR) on the cell surface, triggering a cascade of cellular processes that can influence tissue development and repair. In the context of hair biology, TGF-α is involved in the regulation of hair follicle development and cycling, and its dysregulation can be associated with conditions like alopecia.

Related Terms

Sort by

Research

30 / 1000+ results

research Transforming growth factor-alpha immunoreactivity during induced hair follicle growth cycles in sheep and ferrets.

6 citations , April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

This study suggests that TGF-alpha may function in an autocrine or juxtacrine manner rather than promoting cell proliferation during hair growth cycles in ferrets and sheep.

research Effects of Epidermal Growth Factor and Transforming Growth Factor on Cultured Hair Follicle Cells from Human Scalp

January 1994 in “Skin research”

EGF and TGF-α help maintain hair cell cultures, but TGF-β1 stops their growth.

research Alopesi areata hastalarında serum interferon-gama, tümör nekrozis faktör-alfa, interlökin-13, interlökin-17 ve transforming growth faktör-beta düzeylerinin değerlendirilmesi

January 2016

In this study, serum IL-13 and TGF-β concentrations were significantly different between alopecia areata patients and controls, suggesting a role for these cytokines in the disease's pathogenesis.

research Expression of transforming growth factor-β_1 and tumor necrosis factor-α in mice with radiationinduced pulmonary injury

January 2010 in “Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi”

In this study, increased expression of TGF-β1 and TNF-α was observed in mice after lung irradiation, suggesting these cytokines play a role in radiation-induced pulmonary injury.

research Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata

91 citations , March 1996 in “Archives of Dermatological Research”

This study concluded that cytokines and growth factors significantly regulate hair growth in vitro, with some completely inhibiting growth, such as EGF and TNFα.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

research Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing

70 citations , March 2002 in “Journal of Burn Care & Rehabilitation”

This study found that HB-EGF and TGF-α work together to stimulate wound healing in a murine model of thermal injury, with peak keratinocyte proliferation observed by postburn day five.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research Increment of growth factors in mouse skin treated with non-thermal plasma

18 citations , January 2018 in “International journal of medical sciences”

This study found that non-thermal plasma treatment increased epidermal thickness and dermal collagen density in mouse skin tissue without causing damage, potentially promoting growth factors and tissue remodeling.

Collagen Hydrolysate from Mozambique Tilapia Scales Improves Hair and Skin Health

research Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

2 citations , August 2023 in “Marine drugs”

In this study, fish-derived collagen hydrolysate from tilapia scales improved hair growth and skin health in both cellular and mouse models, reducing oxidative stress and inflammation while enhancing hair quality and promoting beneficial gene expression.

research Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

409 citations , May 1991 in “Genes & Development”

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.

research An in Vitro Model for the Study of Human Hair Growth

13 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study observed that human anagen hair follicles can grow in vitro when maintained serum-free, with possible implications for understanding hair follicle growth mechanisms.

research Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines

March 2023 in “Journal of Applied Biomedicine”

This study suggests that oleanolic acid may promote hair growth in mice with testosterone-induced androgenetic alopecia by activating the Wnt/β-catenin pathway and influencing various molecular levels.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

This review examined and discussed the role of dermis-derived factors in the regulation of melanogenesis, noting their significance in both normal and abnormal mammalian skin conditions, suggesting an underexplored area of study compared to dermal and epidermal influences.

research Comparative Study of Some Potential Paracrine Factors Produced by Normal and Androgenetic Alopecia Hair Follicles

February 2015 in “American journal of medical and biological research”

This study found that molecular differences in paracrine factors between balding and non-balding hair follicles may enhance understanding of androgen action in hair disorders and potentially inform better treatments.

research The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration

January 2010

This study found that αvβ6 integrin inhibits keratinocyte proliferation during wound healing and hair regeneration, suggesting its downregulation may enhance recovery and influence epidermal stem cell behavior.

research Melandrium firmumExtract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice

2 citations , January 2019 in “Annals of Dermatology”

This preliminary study found that Melandrium firmum extract may promote hair growth and inhibit 5α-reductase, suggesting potential as a candidate for treating androgenetic alopecia.

research Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus

1 citations , September 2025 in “PLoS ONE”

This study observed that in mouse fetuses, reticular contraction by actomyosin is involved in dermal regeneration, and differences in actin and α-SMA localization may determine the switch between regeneration and scar formation, suggesting potential insights for wound regeneration therapy.

research The Experimental Studies of YangHyulEum Gami-Bang Extracts on the Hair Growth Effect

1 citations , August 2016 in “Hanbang an'i'bi'in'hu pibu'gwa haghoeji”

In this study using lab models, YangHyulEum Gami-Bang (YHEG) was associated with promoting hair growth and inhibiting factors that contribute to hair loss.

research Regulation of human hair growth: hormones and neuropeptides

January 2016 in “프로그램북(구 초록집)”

This review discusses various hormonal and neuropeptide influences on hair growth and reports no new clinical results; it highlights complexity and suggests areas for future exploration.

research The epidermis: rising to the surface

238 citations , October 1994 in “Current opinion in genetics & development”

This article reviews the role of epidermal proteins and regulatory mechanisms in skin diseases, emphasizing recent insights but reports no new experimental results.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

This study found that ectopic expression of Whn in transgenic mice caused impaired differentiation in epidermis and hair follicles, with hair growth defects and severe urinary tract issues leading to hydronephrosis.

research Epigen Transgenic Mice Develop Enlarged Sebaceous Glands

33 citations , August 2009 in “Journal of Investigative Dermatology”

Overexpressing the epigen gene in mice leads to enlarged sebaceous glands and greasy fur.

research Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses

27 citations , April 2008 in “Journal of Biological Chemistry”

This study found that simvastatin interfered with insulin-induced VEGF expression and keratinocyte proliferation during skin repair in mice, effects that could be reversed by mevalonate.

research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.

research RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells

4 citations , January 2019 in “Annals of Dermatology”

In this study, researchers observed that RE-ORGA, a preparation from Korean herbs, may help alleviate androgenic alopecia by promoting human dermal papilla cell proliferation, reducing 5α-reductase enzyme levels, and displaying anti-inflammatory properties, suggesting potential regulation of androgen receptor sensitivity.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations , January 2011 in “Annals of Dermatology”

This study found that EGFR inhibitors and ligands did not significantly affect the expression of inflammatory biomarkers in cultured sebocytes, except for a notable increase in IL-1 expression with EGF treatment.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

research RETRACTED: Explore the genetic exposure to alopecia areata

2 citations , July 2024 in “Skin Research and Technology”

Copper may protect against alopecia areata, while certain inflammatory markers increase risk.

research News in brief

June 2010 in “Expert Review of Dermatology”

Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.