July 2022 in “Journal of Investigative Dermatology” This study found that the KrasG12D mutation alters ERK signal dynamics in hair follicle stem cells, leading to tissue deformation, and suggests a collective effect of mutant cells is necessary for disruption.
July 2022 in “Biomedicines” This study found that 4-aminopyridine significantly enhanced skin wound healing by accelerating wound closure, improving skin architecture, and promoting hair follicle neogenesis and tissue regeneration.
July 2022 in “Research Square (Research Square)” This study reports that Huaier promotes hair growth and tissue regeneration in cancer recovery by activating the Hedgehog signaling pathway, potentially preventing recurrence and metastasis independently from SMO function.
May 2022 in “Journal of Immunology” In this study, a TGF-β mimic molecule from Heligmosomoides polygyrus was observed to enhance wound healing in mice, with improved tissue regeneration and specific immune cell recruitment without increased scarring.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inhibiting the gp130 Y814 signaling module promotes tissue regeneration and may prevent pathological outcomes after injury in animal models.
This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.
October 2021 in “Austin journal of biomedical engineering” In this study, researchers modified an acellular scaffold with different concentrations of eggshell membrane protein, finding that a 5% concentration effectively enhanced tissue regeneration in mice with excisional wounds, achieving complete healing within 14 days without causing immunogenicity or inflammation.
This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.
April 2020 in “Rice Research Repository (Rice University)” This study suggests that MultiDomain Peptide hydrogels may support wound healing in diabetic mice by accelerating closure and promoting tissue regeneration, though they did not inhibit bacterial growth in infected wounds as expected.
January 2020 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study found that Polycomb Repressive Complex 1 is crucial for maintaining stem cell identity across different lineages, but its loss results in varied transcriptional outcomes depending on the tissue context.
September 2018 in “Digital Access to Scholarship at Harvard (DASH) (Harvard University)” In this study, FN-based fiber scaffolds designed using Rotary Jet-Spinning were shown to enhance wound healing and reduce scar formation in a mouse model, suggesting potential for regenerating healthy skin structure.
February 2018 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study concluded that macrophage iron retention due to Ferroportin inactivation hinders skin wound healing but does not affect liver damage or fibrogenesis in a mouse model.
January 2018 in “eScholarship (California Digital Library)” This study suggests that hair follicle stem cells have a unique metabolic profile that may play a critical role in their maintenance and response to cancer-related changes, potentially contributing to the "Warburg Effect.
August 2017 in “Companion animal” This article discusses the diagnostic approach to focal alopecia in dogs, focusing on distinguishing between pruritic skin disease and inflammatory or non-inflammatory causes; it presents no new experimental results.
December 2016 in “Journal of Pakistan Association of Dermatology” In this study, tissue expansion was identified as a safer initial procedure before hair transplantation for patients with large scalp defects, with the majority of participants having postburn scars and a mean expansion time of 33.6 days.
August 2015 in “PubMed Central” This study suggests that epithelial-derived Pop-Up Keratinocytes (ePUKs) may be a promising cell source for regenerative medicine due to their specific phenotypic traits and their influence on wound healing.
August 2015 in “MOJ proteomics & bioinformatics” This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.
This study introduces a new type of tissue micromodule, the micro tissue precursor (μTP), which can form complex 3D tissues, including lung stroma and skin models supporting hair viability.
January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.
January 2011 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that incorporating dermal papillae cells and keratinocytes into dermal substitutes promoted better wound healing, reduced contraction, and enabled appendage formation in tissue-engineered skin on mice.
December 2009 in “생명과학회지” This study found that thymosin β4 is highly expressed in multiple human tissues and may play a role in organ function and angiogenesis through co-localization with VEGF.
February 2009 in “Journal of The American Academy of Dermatology” This study found that fractional infrared technology may improve skin laxity and thickness in the cervical area without side effects in a small group of patients.
March 2006 in “The FASEB Journal” This study found that incorporating laminin or hair follicles into reconstructed skin grafts on mice improved nerve regeneration and sensory function, suggesting potential for enhancing tactile recovery in burn patients.
September 2004 in “Experimental Dermatology” This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.
February 2020 in “Journal of Physics Conference Series” This study found that laser hair removal is optimal for light to moderate skin tones using 10-15 J/cm² at 755 nm and for dark skin with 4.5-10 J/cm² at 755-1064 nm.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that incorporating Lef-1 transfected dermal papilla cells into human skin equivalents significantly promoted hair follicle differentiation and hair fiber growth, offering a potential advancement for managing skin loss.
57 citations
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April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the vitamin D receptor is crucial for initiating the postnatal hair follicular cycle in mice, preventing alopecia associated with its inactivation.
7 citations
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January 1973 in “Calcified Tissue International” This study found that hair follicle tissue effectively induced mineral formation in calcium phosphate solutions, likely due to its nucleating ability, which was lost when the tissue was lyophilized and stored.
May 2026 in “The EMBO Journal” This study demonstrated how cellular flows and tissue mechanics guide the topological transformations in avian skin, essential for feather follicle development from scales.
58 citations
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January 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study suggests that sexual dimorphism in adipose tissue functions may be linked to androgen levels, as women with PCOS demonstrated a more masculine adipokine expression pattern.