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    Did you mean SMAD signaling?
    Glossary SMAD signaling

    cellular process transmitting signals from surface to nucleus

    SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

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    1. Injectable platelet-rich fibrin promotes proliferation and trichogenic inductivityof dermal papilla cells through activating TGF-β/Smad signaling pathway Cellular and Molecular Biology · 2024 · 4 citations
    2. Kaempferol enhances hair growth by regulating JAK3/STAT6 and TGF-β/Smad signaling in human dermal papilla cells and a C57BL/6 mousemodel Records of Natural Products · 2025
    3. Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Research Square (Research Square) · 2020
    4. Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway Inflammopharmacology · 2026
    5. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    6. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    7. TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition Cold Spring Harbor Perspectives in Biology · 2017 · 82 citations
    8. Polysulfonic acid mucopolysaccharide exerts anti scarring effect in rats through modulation of TGF β 1/Smad signaling pathway Tropical Journal of Pharmaceutical Research · 2023 · 1 citations
    9. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
    10. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    11. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    12. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle Journal of Molecular Cell Biology · 2018 · 26 citations
    13. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair Burns & Trauma · 2026
    14. Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice Journal of Cosmetic Dermatology · 2018 · 21 citations
    15. P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression Stem Cell Research & Therapy · 2016 · 24 citations
    16. Kartogenin regulates hair growth and hair cycling transition International Journal of Medical Sciences · 2022 · 2 citations
    17. Transforming growth factor-β in stem cells and tissue homeostasis Bone Research · 2018 · 245 citations
    18. RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells Frontiers in Bioengineering and Biotechnology · 2024 · 6 citations
    19. Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways Molecules · 2026
    20. The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration 2010
    21. Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats Stem Cell Research & Therapy · 2024 · 11 citations
    22. Pathological Skin Scarring: From Mechanism to Targeted Local Therapy Preprints.org · 2026
    23. Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway Frontiers in Pharmacology · 2019 · 58 citations
    24. TGF-β family signaling in stem cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012 · 132 citations
    25. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway International Journal of Biological Sciences · 2023 · 9 citations
    26. Co-opting Developmental Signaling Pathways to Promote Wound Healing Recent clinical techniques, results, and research in wounds · 2018 · 1 citations
    27. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    28. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    29. An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia Medicine · 2016 · 18 citations
    30. Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades Biochemical and Biophysical Research Communications · 2016 · 14 citations