Search

for
Search:

Did you mean Terminal Differentiation?

Glossary Terminal Differentiation

cell's final development into a specialized, non-dividing state

Terminal differentiation is the process by which a cell undergoes its final stage of development, becoming a specialized cell type with a specific function, such as a skin cell or a neuron. Once a cell has terminally differentiated, it typically loses the ability to divide and produce new cells, focusing instead on performing its specialized role. This process is crucial for the proper functioning of tissues and organs in the body.

Related Terms

Sort by

Research

30 / 1000+ results

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

research Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation

23 citations , January 1986

This review discusses the chemical stability of protein envelopes found in the epidermis and other stratified squamous epithelia, but reports no new clinical results.

research Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation

42 citations , June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.

research Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.

104 citations , July 1994 in “The Journal of Cell Biology”

This study suggests that basonuclin in keratinocytes is likely a regulatory molecule linked to maintaining proliferative capacity and preventing terminal differentiation rather than a cell cycle marker.

research Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23

January 2023 in “Journal of cosmetic dermatology”

This study found that the synthetic retinoid EC23 effectively induces keratinocyte hyperproliferation and enhances hair growth in mice, showing more potency than all-trans retinoic acid.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

research Selective Expression of Calcium-Binding Proteins S100A8 and S100A9 at Distinct Sites of Hair Follicles

22 citations , September 2001 in “Journal of Investigative Dermatology”

S100A8 and S100A9 proteins help form hair shafts during growth.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

This study observed that CIP/KIP proteins play a significant role in regulating cell cycle arrest and differentiation in human hair follicles, supporting hair growth and formation in the anagen phase.

research Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin

96 citations , December 2002 in “Experimental dermatology”

This study found that NGAL expression in embryonic skin is spatio-temporally regulated and strongly induced in adult skin conditions with dysregulated differentiation, suggesting a role in epithelial differentiation pathways.

research The cDNA-deduced amino acid sequence for trichohyalin, a differentiation marker in the hair follicle, contains a 23 amino acid repeat.

39 citations , February 1990 in “The journal of cell biology/The Journal of cell biology”

This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

35 citations , June 2012 in “PloS one”

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

research Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells.

25 citations , October 2005 in “PubMed”

This study found that keratin 19 and nuclear galectin-1 binding can transiently express in interfollicular epidermal cells after adhesion, suggesting keratin 19 should not be solely used as a stem cell activity marker.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.

research A practical guide for the study of human and murine sebaceous glands in situ

56 citations , September 2013 in “Experimental Dermatology”

This guide reviews the biology of sebaceous glands and their evaluation methods, emphasizing their roles beyond lipid production in skin health and disease, and reports no new research results.

research Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes

49 citations , March 2004 in “Journal of Investigative Dermatology”

This study found that the hHa7 gene in hair follicle trichocytes is the first identified to have its expression directly regulated by androgens, suggesting it as a marker for androgen action on hair follicles.

research Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo

46 citations , May 2003 in “Mechanisms of Development”

This study found that overexpression of the calcium sensing receptor in transgenic mice accelerates epidermal differentiation and hair growth, suggesting its role in enhancing calcium signaling and interaction with other pathways.

research A function for Rac1 in the terminal differentiation and pigmentation of hair

11 citations , January 2012 in “Journal of cell science”

This study demonstrates that Rac1 activity is essential for normal hair follicle formation but influences hair structure and pigmentation, in terminal differentiation, through alterations in hair shaft, cuticle, and pigmentation organization.

Knockout of mTOR/Akt Inhibitor REDD1 Results in Hair Cycle-Independent Dermal Adipose Expansion by Promoting Adipocyte Differentiation

research 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation

April 2019 in “Journal of Investigative Dermatology”

This study found that mice lacking REDD1 experienced an expansion of dermal white adipose tissue through both hypertrophy and hyperplasia, suggesting a potential therapeutic target for skin adipogenesis regulation.

research Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold

29 citations , April 2020 in “Biomolecules”

The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.

research Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro

24 citations , February 2015 in “Experimental Cell Research”

This study found that overexpression of the transcription factor NFIC may enhance the proliferation and differentiation of stem cells from the apical papilla, suggesting its potential role in dentin/root regeneration.

research The role of cathepsin E in terminal differentiation of keratinocytes

15 citations , April 2011 in “Biological Chemistry”

This study found that Cathepsin E plays a crucial role in keratinocyte terminal differentiation, affecting epidermis formation and homeostasis in mice.

research NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells

11 citations , August 2019 in “Journal of Molecular Histology”

This study found that upregulation of NFIC may enhance proliferation and osteogenic/cementogenic differentiation in rat dental follicle cells.

research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting

76 citations , June 2015 in “Journal of biomedical science”

This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.

research Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages

7 citations , October 2024 in “Cells”

The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.

Human Skin Stem Cells and the Aging Process

research Human skin stem cells and the ageing process

143 citations , September 2008 in “Experimental gerontology”

This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.

research Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

31 citations , April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that active androgens activate lipogenic differentiation in human sebocytes expressing a functional androgen receptor, influencing gene expression and lipid synthesis, while also increasing apoptotic cell population over time.

research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation

25 citations , October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study characterized the mouse profilaggrin gene, finding it structurally identical to its human counterpart, and noted differences in protein-coding regions that could impact epidermal differentiation.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

24 citations , January 2016 in “Lasers in Medical Science”

This study found that non-ablative fractional erbium glass laser treatment affected gene regulation in human skin models by downregulating MMP and interleukin expression, suggesting potential roles in dermal remodeling and anti-inflammatory effects.

research From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy

9 citations , November 2018 in “Journal of cosmetic dermatology”

This study reports that a plant extract from Orobanche rapum can stimulate skin rejuvenation and protect cutaneous microbiota, potentially creating healthier skin.

Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis

research Epithelial Skin Biology

118 citations , January 2016 in “Current Topics in Developmental Biology”

This essay discusses the establishment, maintenance, and role of skin stem cells in tissue homeostasis, wound repair, and their relation to skin cancer, without reporting new experimental findings.