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    Glossary Systemic Side Effects

    unintended effects of a treatment affecting the entire body

    Systemic Side Effects, also known as Systemic Adverse Effects or Systemic Reactions, refer to unintended effects of a medication or treatment that affect the entire body rather than just a specific area. For example, a drug prescribed for hair loss might cause nausea, dizziness, or changes in blood pressure, impacting multiple organ systems rather than just the scalp.

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    1. Lack of endocrine systemic side effects after topical application of spironolactone in man Journal of endocrinological investigation · 1988 · 8 citations
    2. Glucocorticoid-Induced Side Effects Cause Oral Lesions in Systemic Lupus Erythematosus: A Case Report International Medical Case Reports Journal · 2024
    3. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018
    4. Systemic retinoids and thyrotoxicosis in (Multi) nodular goiter: Side effect or coincidence? 2018 · 1 citations
    5. Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects Journal of Clinical Medicine · 2021 · 15 citations
    6. A Comparison of the Efficacy, Relapse Rate and Side Effects among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006 · 97 citations
    7. A Comparison of the Efficacy, Relapse Rate and Side Effects among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Yearbook of Dermatology and Dermatologic Surgery · 2007
    8. Cyclophosphamide: As bad as its reputation? Long-term single centre experience of cyclophosphamide side effects in the treatment of systemic autoimmune diseases Schweizerische medizinische Wochenschrift · 2014 · 39 citations
    9. Cutaneous Side Effects of Chemotherapy and Radiotherapy 2016 · 2 citations
    10. Potential PRP Hair Treatment Side Effects 2017
    11. A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014 · 50 citations
    12. International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women Climacteric · 2021 · 9 citations
    13. Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital Anais Brasileiros de Dermatologia · 2021 · 7 citations
    14. International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women Journal of Womens Health · 2021 · 20 citations
    15. International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women The Journal of Sexual Medicine · 2021 · 30 citations
    16. Incidence of androgenic dermatologic side effects following placement of a levonorgestrel intrauterine device for menorrhagia: A survey-based study Journal of the American Academy of Dermatology · 2017 · 11 citations
    17. Synergistic therapeutic effect of systemic steroids and dithranol in a patient of alopecia totalis—A case report 2026
    18. Side Effects’ Frequency Assessment of Low Dose Oral Minoxidil in Male Androgenetic Alopecia Patients Skin Appendage Disorders · 2024
    19. Supplementary Material for: Additive Effects of Platelet-Rich Plasma and Systemic Therapies in Androgenetic Alopecia: A Retrospective Study Figshare · 2026
    20. Effects of local and systemic medications on eye health: Adverse reactions Hospital Pharmacology - International Multidisciplinary Journal · 2025
    21. Comparing Adherence, Side Effects, and Satisfaction in Oral and Topical Minoxidil: A Cross-Sectional Study Journal of Drugs in Dermatology · 2025
    22. 69 Risk-benefit appraisal of systemic JAK inhibitors for alopecia areata: a comprehensive meta-analysis assessing safety and adverse effects Journal of Investigative Dermatology · 2023
    23. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis Journal of the American Academy of Dermatology · 2003 · 146 citations
    24. Drug delivery to hair follicles Expert opinion on drug delivery · 2013 · 122 citations
    25. Percutaneous Absorption of Minoxidil in Man Archives of Dermatology · 1985 · 52 citations
    26. Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome Pediatric dermatology · 2007 · 42 citations
    27. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial Journal of The European Academy of Dermatology and Venereology · 2021 · 11 citations
    28. Patient preferences in the treatment of alopecia areata: A review of the literature JAAD reviews. · 2024 · 1 citations
    29. What are the best treatments for hair loss in dialysis patients? Open MIND · 2026
    30. What are the best treatments for hair loss in dialysis patients? Zenodo (CERN European Organization for Nuclear Research) · 2026