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    Glossary Stem Cell Secretome

    collection of bioactive molecules secreted by stem cells

    The stem cell secretome refers to the collection of bioactive molecules, such as proteins, lipids, and nucleic acids, that are secreted by stem cells. These molecules play a crucial role in cell communication, tissue repair, and regeneration by influencing the behavior of surrounding cells. For professionals, understanding the stem cell secretome is essential for developing therapies for conditions like alopecia, where promoting hair follicle regeneration is key.

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    1. Stem cell secretome as a new booster for regenerative medicine Bioscience trends · 2019 · 54 citations
    2. Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics Cell proliferation · 2023 · 3 citations
    3. Therapeutic and Clinical Potential of Adipose-Derived Stem Cell Secretome for Skin Regeneration Cells · 2025 · 2 citations
    4. Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review Journal of Biomedical Science · 2022 · 2 citations
    5. Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial Preprints.org · 2026
    6. Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions Preprints.org · 2025
    7. CASE REPORT: SUCCESSFUL TREATMENT OF ALOPECIA WITH UMBILICAL CORD MESENCHYMAL STEM CELL AND MESENCHYMAL STEM CELL-DERIVED SECRETOME COMBINATION Cytotherapy · 2024
    8. Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study Stem Cell Research & Therapy · 2025
    9. Stem cell–derived secretome: a novel strategy for wound healing Frontiers in Pharmacology · 2026
    10. Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia Biosaintifika Journal of Biology & Biology Education · 2024
    11. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Pharmacology & Therapeutics · 2016 · 26 citations
    12. Adipose-derived Stem Cell Secretome and Its Potential Role in the Treatment of Androgenetic Alopecia Plastic and reconstructive surgery. Global open · 2021
    13. Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation Journal of Bioscience and Bioengineering · 2026
    14. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017 · 773 citations
    15. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021 · 26 citations
    16. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review Stem Cell Research & Therapy · 2025 · 9 citations
    17. THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES International Journal of Applied Pharmaceutics · 2026
    18. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration Stem Cells International · 2018 · 9 citations
    19. Hair follicle stem cell-derived secretome protects astrocytes in an in vitro ischemia/reperfusion model Anatomy & Cell Biology · 2025
    20. Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-II 2024
    21. Limbal Mesenchymal Stem Cell Secretome as Potential Adjuvant Therapy for Ocular Alkali Injury 2022
    22. Dual Traditional Chinese Medicine-Preconditioned Stem Cell Secretomes in Coaxial Electrospun Nanofibers Synergistically Accelerate Diabetic Wound Regeneration bioRxiv (Cold Spring Harbor Laboratory) · 2026
    23. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome Cells · 2019 · 271 citations
    24. Different levels of EGF, VEGF, IL‐6, MCP‐1, MCP‐3, IP‐10, Eotaxin and MIP‐1α in the adipose‐derived stem cell secretome in androgenetic alopecia Experimental Dermatology · 2022 · 1 citations
    25. Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups 2024
    26. Stem Cell-Based Therapies for Hair Loss: What is the Evidence from a Clinical Perspective? Stem cell biology and regenerative medicine · 2022
    27. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    28. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    29. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging Clinical Cosmetic and Investigational Dermatology · 2023 · 22 citations
    30. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023