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    Glossary Stem Cell Secretome

    collection of bioactive molecules secreted by stem cells

    The stem cell secretome refers to the collection of bioactive molecules, such as proteins, lipids, and nucleic acids, that are secreted by stem cells. These molecules play a crucial role in cell communication, tissue repair, and regeneration by influencing the behavior of surrounding cells. For professionals, understanding the stem cell secretome is essential for developing therapies for conditions like alopecia, where promoting hair follicle regeneration is key.

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    Research 30 of 1000+

    1. Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics Cell proliferation · 2023 · 3 citations
    2. Therapeutic and Clinical Potential of Adipose-Derived Stem Cell Secretome for Skin Regeneration Cells · 2025 · 2 citations
    3. Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia Biosaintifika Journal of Biology & Biology Education · 2024
    4. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017 · 773 citations
    5. Limbal Mesenchymal Stem Cell Secretome as Potential Adjuvant Therapy for Ocular Alkali Injury 2022
    6. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome Cells · 2019 · 271 citations
    7. Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review Journal of Biomedical Science · 2022 · 2 citations
    8. CASE REPORT: SUCCESSFUL TREATMENT OF ALOPECIA WITH UMBILICAL CORD MESENCHYMAL STEM CELL AND MESENCHYMAL STEM CELL-DERIVED SECRETOME COMBINATION Cytotherapy · 2024
    9. Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial Preprints.org · 2026
    10. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Pharmacology & Therapeutics · 2016 · 26 citations
    11. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review Stem Cell Research & Therapy · 2025 · 9 citations
    12. Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells Journal of Tissue Engineering · 2026
    13. CLINICAL INSIGHTS FOR HAIR RESTORATION: A CASE STUDY ON UC-MSCs DERIVED SECRETOME THERAPY IN ALOPECIA Cytotherapy · 2025
    14. Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles Stem Cell Research & Therapy · 2020 · 60 citations
    15. Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies Journal of Translational Medicine · 2025 · 16 citations
    16. Current advances in stem cell-based therapies for hair regeneration European Journal of Pharmacology · 2020 · 32 citations
    17. The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells (SH-MSCs) on IL-6 and TGF- β Gene Expression (Experimental Study in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole) International journal of multidisciplinary research and analysis · 2023
    18. Secretome-Based Therapy Promotes Epidermal Thickness Recovery and Follicular Regrowth in Fluconazole-Induced Alopecia in Rats International Journal of Cell and Biomedical Science · 2025
    19. Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions Preprints.org · 2025
    20. Stem cell secretome as a new booster for regenerative medicine Bioscience trends · 2019 · 54 citations
    21. Hair follicle stem cell-derived secretome protects astrocytes in an in vitro ischemia/reperfusion model Anatomy & Cell Biology · 2025
    22. Hair regeneration: Mechano-activation and related therapeutic approaches. PubMed · 2025
    23. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging Clinical Cosmetic and Investigational Dermatology · 2023 · 22 citations
    24. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021 · 26 citations
    25. Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups 2024
    26. Stem Cell Therapy for Burns: Story so Far 2021
    27. Stem cell–derived secretome: a novel strategy for wound healing Frontiers in Pharmacology · 2026
    28. Adipose-derived Stem Cell Secretome and Its Potential Role in the Treatment of Androgenetic Alopecia Plastic and reconstructive surgery. Global open · 2021
    29. Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of their in Vitro Wound Healing Potential 2025
    30. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration Stem Cells International · 2018 · 9 citations