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    Glossary Stem Cell Secretome

    collection of bioactive molecules secreted by stem cells

    The stem cell secretome refers to the collection of bioactive molecules, such as proteins, lipids, and nucleic acids, that are secreted by stem cells. These molecules play a crucial role in cell communication, tissue repair, and regeneration by influencing the behavior of surrounding cells. For professionals, understanding the stem cell secretome is essential for developing therapies for conditions like alopecia, where promoting hair follicle regeneration is key.

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    1. Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions Preprints.org · 2025
    2. Adipose-derived Stem Cell Secretome and Its Potential Role in the Treatment of Androgenetic Alopecia Plastic and reconstructive surgery. Global open · 2021
    3. Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies Frontiers in Cell and Developmental Biology · 2026
    4. Therapeutic and Clinical Potential of Adipose-Derived Stem Cell Secretome for Skin Regeneration Cells · 2025 · 2 citations
    5. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016 · 42 citations
    6. 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge? 2022
    7. Nanovesicles from Adipose Derived Stem Cells Delay Hair Follicle Degeneration and Stimulate Regeneration: a Novel Therapeutic Strategy for Androgenetic Alopecia Stem Cell Reviews and Reports · 2025
    8. A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective International Journal of Molecular Sciences · 2022 · 8 citations
    9. Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization Stem Cell Research & Therapy · 2022 · 24 citations
    10. Modern aspects of external application and prospects of using the secretome of mesenchymal stem cells (review) Drug development & registration · 2024
    11. Exploring the Differentiation Abilities of Hair Follicle and Dental Pulp Stem Cells Into Islet Like Cells Cell Biology International · 2025 · 1 citations
    12. Stem cell–based therapies Elsevier eBooks · 2023
    13. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014 · 10 citations
    14. Advances in Hair Restoration Current Otorhinolaryngology Reports · 2021
    15. Recent advances in electrospun nanofibers for wound healing Nanomedicine · 2017 · 262 citations
    16. Beyond acne: Current aspects of sebaceous gland biology and function Reviews in Endocrine and Metabolic Disorders · 2016 · 97 citations
    17. Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention Frontiers in Cell and Developmental Biology · 2021 · 61 citations
    18. Deciphering the functions of the hair follicle infundibulum in skin physiology and disease Cell and Tissue Research · 2014 · 38 citations
    19. DataSheet2_Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention.PDF OPAL (Open@LaTrobe) (La Trobe University) · 2021
    20. Gate keeping the sebaceous gland bioRxiv (Cold Spring Harbor Laboratory) · 2023
    21. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction Journal of Dermatological Science · 2017 · 35 citations
    22. Therapeutic Effect of a Xeno-Free Three-Dimensional Stem Cell Mass in a Hind Limb Ischemia Model Tissue Engineering Part A · 2018 · 2 citations
    23. LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway Stem cell research & therapy · 2016 · 53 citations
    24. Erratum to: Clinical Efficacy of a Cosmetic Treatment by Crescina® Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia Dermatology and therapy · 2013
    25. 3D co-culture model of endothelial colony-forming cells (ECFCs) reverses late passage adipose-derived stem cell senescence for wound healing Stem Cell Research & Therapy · 2020 · 17 citations
    26. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023
    27. Stem Cell Therapy for Burns: Story so Far Biologics · 2021 · 24 citations
    28. Hair growth-promoting effect of human dermal stem/progenitor cell-derived conditioned medium Tissue Engineering and Regenerative Medicine · 2015 · 9 citations
    29. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence Yearbook of pediatric endocrinology · 2021
    30. Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation Journal of Bioscience and Bioengineering · 2026