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    Did you mean Stem Cell Factor?
    Glossary Stem Cell Factor

    protein crucial for stem cell survival and differentiation

    Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

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    1. The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate Trends in cell biology · 2018 · 33 citations
    2. <i>N</i>1-acetylspermidine is a determinant of hair follicle stem cell fate Journal of Cell Science · 2021 · 17 citations
    3. Fibronectin meshwork controls epithelial stem cell fate bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    4. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    5. Epidermal stem cell fate: what can we learn from embryonic stem cells? 2007 · 15 citations
    6. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    7. Editorial: Directing Stem Cell Fate Using Plant Extracts and Their Bioactive Compounds Frontiers in Cell and Developmental Biology · 2022 · 4 citations
    8. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    9. Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · 2017 · 3 citations
    10. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nature cell biology · 2023 · 6 citations
    11. 1349 Inducing fate changes at the hair follicle stem cell nice Journal of Investigative Dermatology · 2023
    12. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    13. Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging Molecular Metabolism · 2022 · 22 citations
    14. Retinoic acids shift skin stem cell fate Journal of Investigative Dermatology · 2026
    15. Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle‐dependent manner Experimental dermatology · 2019 · 16 citations
    16. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling npj Regenerative Medicine · 2022 · 3 citations
    17. Fatty acid oxidation fuels mitochondrial respiration to drive epidermal stem cell fate and differentiation Nature Communications · 2026
    18. Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa Journal of the European Academy of Dermatology and Venereology · 2025
    19. The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Cell Metabolism · 2025
    20. Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential bioRxiv (Cold Spring Harbor Laboratory) · 2021
    21. Role of Notch signaling in cell fate determination of dental epithelial stem/progenitor cells Zurich Open Repository and Archive (University of Zurich) · 2017
    22. Functional endoscopy techniques for tracking stem cell fate Quantitative Imaging in Medicine and Surgery · 2019 · 5 citations
    23. Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    24. 1442 Neurotransmitter signaling specify sweat gland stem cell fate through intracellular calcium regulation Journal of Investigative Dermatology · 2023
    25. 1323 The effects of 3-OH of kaempferol on interfollicular epidermal stem cell fate Journal of Investigative Dermatology · 2018
    26. Spatial organization within a niche as a determinant of stem-cell fate Nature · 2013 · 394 citations
    27. Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    28. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate 2023 · 1 citations
    29. Cell fate decisions: emerging roles for metabolic signals and cell morphology EMBO Reports · 2017 · 100 citations
    30. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day Development · 2014 · 91 citations