33 citations,
March 2018 in “Trends in cell biology” Metabolism plays a key role in determining stem cell fate.
15 citations,
September 2007 in “Cell & tissue research/Cell and tissue research” Embryonic and adult stem cells are valuable for improving skin grafts and cell therapy.
51 citations,
September 2020 in “Cell Metabolism” Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.
57 citations,
March 2018 in “International Journal of Molecular Sciences” The extracellular matrix is crucial for controlling skin stem cell behavior and health.
6 citations,
July 2023 in “Nature cell biology” SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
139 citations,
August 2018 in “Development” The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
3 citations,
December 2022 in “npj Regenerative Medicine” HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
1 citations,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Polyamines are important in deciding hair follicle stem cell behavior, affecting hair growth and loss.
April 2018 in “Journal of Investigative Dermatology” Kaempferol helps skin stem cells grow and may improve skin thickness due to its 3-OH group.
1 citations,
June 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Vitamin D helps skin stem cells heal wounds by working with a key skin protein.
April 2021 in “Journal of Investigative Dermatology” Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Elf5 is important for skin stem cell growth and could help treat skin and hair problems.
9 citations,
November 2020 in “The FASEB journal” Intermediate filaments are crucial for cell differentiation and stem cell function.
100 citations,
November 2017 in “EMBO Reports” Metabolic signals and cell shape influence how cells develop and change.
91 citations,
August 2014 in “Development” The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Developing hair follicles form from ring-shaped patterns, with future stem cells originating from the outer ring, not the upper layers, as previously thought.
214 citations,
April 2017 in “Cell” Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
73 citations,
April 2013 in “Stem cells” LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
28 citations,
February 2019 in “Genes” Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
4 citations,
May 2014 in “Biochemical Society Transactions” Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.
January 2016 in “Elsevier eBooks” The conclusion is that grasping how cells determine their roles through evolution is key, with expected progress from new research models and genome editing.
137 citations,
April 2015 in “Nature Reviews Molecular Cell Biology” Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.
135 citations,
December 2013 in “Seminars in Cell & Developmental Biology” Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.
31 citations,
May 2015 in “Stem Cell Reports” Stem cells and their surrounding environment in hair follicles work closely together, affecting hair growth and having implications for cancer and tissue regeneration.
26 citations,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.
April 2017 in “Journal of Investigative Dermatology” PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.
82 citations,
March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
34 citations,
April 2018 in “EMBO journal” The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.