Search
for

    Did you mean Stem Cell Factor?
    Glossary Stem Cell Factor

    protein crucial for stem cell survival and differentiation

    Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010 · 10 citations
    2. Immunohistochemical study assessing stem cell factor receptor C-kit in patients with alopecia Egyptian Journal of Dermatology and Venereology · 2020
    3. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    4. 1049 Novel strategy to promote hair follicle growth and stem cell activation in human male scalp skin: Targeting prolactin receptor with ABS-201 Journal of Investigative Dermatology · 2026
    5. The Epithelial Stem Cell Niche in Skin Elsevier eBooks · 2017 · 9 citations
    6. Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair Advances in Wound Care · 2019 · 10 citations
    7. 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction 2023
    8. Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation Molecular therapy · 2014 · 13 citations
    9. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    10. 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege 2023
    11. Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege bioRxiv (Cold Spring Harbor Laboratory) · 2023
    12. The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp. 2010
    13. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    14. A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control Experimental Dermatology · 2004 · 2 citations
    15. Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications Current Issues in Molecular Biology · 2026
    16. Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin Stem Cells · 2013 · 43 citations
    17. Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells Journal of Tissue Engineering · 2026
    18. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    19. 546 Epidermal growth factor receptor as a key regulator of the immune privilege Journal of Investigative Dermatology · 2022
    20. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    21. ISID1338 - Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction 2023
    22. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate 2023 · 1 citations
    23. [Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses]. PubMed · 2002 · 12 citations
    24. The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding Receptors · 2024
    25. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity 2023
    26. Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment Stem Cells · 2012 · 14 citations
    27. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 2 citations
    28. 1233 Exploring the role of melanocyte subpopulations in vitiligo 2023
    29. Hair graying and loss induced by imatinib mesylate The Journal of Dermatology · 2013 · 7 citations
    30. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations