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    Glossary Stem Cell Aging

    gradual decline in stem cells' function and regenerative ability

    Stem cell aging refers to the gradual decline in the function and regenerative capacity of stem cells as they age. This process can lead to reduced tissue repair and regeneration, contributing to aging-related diseases and conditions, including hair loss and alopecia. For professionals, it involves understanding the molecular and cellular mechanisms, such as DNA damage, oxidative stress, and changes in the stem cell niche, that drive this decline.

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    1. Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging Frontiers in Aging · 2023 · 3 citations
    2. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    3. Editorial: Stem cell exhaustion in aging Frontiers in Aging · 2024 · 13 citations
    4. The Anti-Aging Effects of Adipose-Derived Mesenchymal Stem Cell Exosomes on Skin and Their Potential for Personalized Skincare Applications Clinical Cosmetic and Investigational Dermatology · 2025 · 1 citations
    5. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    6. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging Aging Cell · 2020 · 23 citations
    7. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    8. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    9. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs Journal of Cosmetic Dermatology · 2015 · 36 citations
    10. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair Theranostics · 2022 · 9 citations
    11. Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    12. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    13. 1431 Skin aging and hair follicle stem cell dysfunction caused by T cells with defective mitochondrial metabolism Journal of Investigative Dermatology · 2023
    14. Collagen XVIIα1 in skin and hair aging: Mechanisms, stem cell niche regulation, and translational strategies Journal of Dermatological Science · 2026
    15. Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging Journal of Clinical Oncology · 2008 · 2 citations
    16. ANTI-AGING EFFECTS OF MESENCHYMAL STEM CELL-CONDITIONED MEDIUM IN MICE SKIN MODEL INDUCED BY D-GALACTOSE 2017
    17. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging Clinical Cosmetic and Investigational Dermatology · 2023 · 22 citations
    18. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    19. Histological Study of Skin Aging Model Treated with Topical Mesenchymal Stem Cell-Conditioned Medium 2017
    20. Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology bioRxiv (Cold Spring Harbor Laboratory) · 2026
    21. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells Else Kröner-Fresenius Symposia · 2012
    22. The Role of Box A of<i>HMGB1</i>in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy 2023 · 1 citations
    23. 23 Efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging: a 12-week prospective, randomized, split-face study 2023
    24. 567 Skin aging and carcinogenesis mechanisms by focusing on the stem cell competitive dynamics Journal of Investigative Dermatology · 2022
    25. Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders International Journal of Molecular Sciences · 2024
    26. Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging Molecular Metabolism · 2022 · 22 citations
    27. The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells International Journal of Molecular Sciences · 2020 · 3 citations
    28. Aging of hair follicle stem cells and their niches Journal of Biochemistry and Molecular Biology · 2022 · 2 citations
    29. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    30. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022