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    Glossary Skin Microenvironment

    complex and dynamic environment within the skin influencing health

    The skin microenvironment refers to the complex and dynamic environment within the skin, including various cell types, extracellular matrix components, and signaling molecules. It plays a crucial role in maintaining skin health, influencing processes like wound healing, immune responses, and hair growth. Understanding the skin microenvironment is essential for developing treatments for conditions like alopecia and other skin disorders.

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    1. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    2. Epidermal stem cells: Interplay with the skin microenvironment during wound healing Molecules and Cells · 2024 · 5 citations
    3. The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease Biomolecules · 2025
    4. Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    5. Nanotechnological reprogramming of the pathological skin microenvironment in scar formation and atopic dermatitis Journal of Pharmaceutical Investigation · 2026
    6. Regeneration of hair and other skin appendages: A microenvironment‐centric view Wound Repair and Regeneration · 2016 · 10 citations
    7. Injectable Photocuring Silk Fibroin-Based Hydrogel Constructs Antioxidant Microenvironment for Skin Repair 2023
    8. Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration 2017 · 3 citations
    9. An injectable photocuring silk fibroin-based hydrogel for constructing an antioxidant microenvironment for skin repair Journal of Materials Chemistry B · 2024 · 15 citations
    10. Cellular heterogeneity and microenvironmental control of skin cancer Journal of Internal Medicine · 2020 · 16 citations
    11. Microvascular Remodeling Strategy for Skin Rejuvenation through Microenvironmental Reprogramming and Appendage Restoration Biomaterials · 2026
    12. Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing Science Advances · 2021 · 66 citations
    13. Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases Frontiers in immunology · 2023 · 3 citations
    14. Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro Mendeley Data · 2026
    15. Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro bioRxiv (Cold Spring Harbor Laboratory) · 2025
    16. Biophysical and Metabolic Cues in the Microenvironment of Skin Wounds: Implications for Stem Cell Behaviour and Epidermal Regeneration MEDS Clinical Medicine · 2026
    17. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    18. Fascia Layer—A Novel Target for the Application of Biomaterials in Skin Wound Healing International Journal of Molecular Sciences · 2023 · 1 citations
    19. Hafnium Oxide Nanostructure-IntegratedSilk FibroinMicroneedles Reshape Cutaneous Melanocyte Microenvironment for VitiligoTherapy Figshare · 2026
    20. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    21. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    22. Green fabrication of seedbed-like Flammulina velutipes polysaccharides–derived scaffolds accelerating full-thickness skin wound healing accompanied by hair follicle regeneration International Journal of Biological Macromolecules · 2020 · 14 citations
    23. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Nature Reviews Molecular Cell Biology · 2015 · 137 citations
    24. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles Burns & Trauma · 2021 · 65 citations
    25. Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration Military Medical Research · 2024 · 37 citations
    26. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021 · 22 citations
    27. Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis Cell · 2020 · 2 citations
    28. Skin‐on‐a‐chip strategies for human hair follicle regeneration Experimental Dermatology · 2022
    29. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014 · 42 citations
    30. Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth Proceedings of the National Academy of Sciences of the United States of America · 2013 · 256 citations