Search
for

    Glossary Skin Barrier Integrity

    outermost skin layer's health and protective function

    Skin Barrier Integrity refers to the health and functionality of the outermost layer of the skin, which acts as a protective shield against environmental threats like bacteria, chemicals, and moisture loss. Maintaining this integrity is crucial for preventing infections, irritation, and conditions like eczema, as well as for overall skin health.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model Barrier Immunity · 2025 · 1 citations
    2. LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants Journal of Investigative Dermatology · 2025
    3. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations
    4. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    5. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    6. Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes Frontiers in Immunology · 2021 · 9 citations
    7. Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance Journal of Biological Chemistry · 2013 · 67 citations
    8. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    9. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    10. The genetic basis of dermatophytosis skin infection susceptibility Nature Communications · 2026
    11. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin International Journal of Molecular Sciences · 2025
    12. The role of the skin microbiome in wound healing Burns and trauma · 2023
    13. Screening of Microbial Strains Used to Ferment Dendrobium officinale to Produce Polysaccharides, and Investigation of These Polysaccharides’ Skin Care Effects Processes · 2023
    14. 779 Multicellular skin organoids as a unique modeling platform for skin physiology, injury, and disease Journal of Investigative Dermatology · 2024
    15. Transcriptomic Analysis Provides Molecular Insights into Skin Development in Dezhou Donkey Foals Veterinary Sciences · 2026
    16. Decay of Skin-Specific Gene Modules in Pangolins Journal of molecular evolution · 2023 · 1 citations
    17. Convergent Decay of Skin-specific Gene Modules in Pangolins bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    18. The impact of different hair‐removal behaviours on the biophysical and biochemical characteristics of female axillary skin International Journal of Cosmetic Science · 2020 · 4 citations
    19. Expression and Function of Group IIE Phospholipase A2 in Mouse Skin 2016 · 26 citations
    20. The Role of Linoleic Acid in Skin and Hair Health: A Review International Journal of Molecular Sciences · 2024
    21. Eavesdropping on the conversation between immune cells and the skin epithelium International Immunology · 2019 · 10 citations
    22. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    23. Acne and sebaceous gland function Clinics in dermatology · 2004 · 463 citations
    24. Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice PLOS genetics · 2020 · 23 citations
    25. Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development Frontiers in Cell and Developmental Biology · 2020 · 12 citations
    26. Reversing Time with Peptides: Mechanisms, Classifications, and Innovations in Anti-aging Interventions Commagene Journal of Biology · 2026
    27. Targeting the Gut Microbiota with Pro- and Postbiotics: Emerging Strategies against Alopecia Probiotics and Antimicrobial Proteins · 2026
    28. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    29. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    30. Expanding the Cutaneous Spectrum of Nicolaides‑Baraitser Syndrome: Eczema and Generalized Hair Loss Cureus · 2025