46 citations
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April 2021 in “International Journal of Molecular Sciences” This review discusses the potential of curcumin and its formulations to mitigate neuropathic and postoperative pain, highlighting positive outcomes in preclinical and clinical studies but noting the need for further clinical research.
18 citations
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January 2022 in “Nutrients” This review discusses potential agents, including acetyl-L-carnitine and vitamins, for repurposing in managing chemotherapy-induced peripheral neuropathy and reports no clinical results; the authors emphasize the need for further research.
73 citations
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January 1994 in “European Urology” This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.
28 citations
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January 2009 in “Journal of Cutaneous and Aesthetic Surgery” This article discusses Serenoa repens for androgenetic alopecia and reports no strong evidence of its effectiveness, emphasizing the need for larger clinical trials.
24 citations
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June 2018 in “PubMed” This study found that liposterolic extracts of Serenoa repens enhanced hair regeneration and repair in DHT-induced hair loss mouse models, suggesting potential effects comparable to finasteride.
12 citations
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January 1998 in “Endocrine journal” Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.
6 citations
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October 2012 in “Pediatrics” This case report describes an 11-year-old girl who experienced hot flashes and menarche after taking a Serenoa repens supplement for telogen effluvium, suggesting a possible but uncertain link between the supplement and hormonal changes.
3 citations
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August 2021 in “Uro” This review concludes that global literature supports the lipidosterolic extract of Serenoa repens as efficacious and safe for treating lower urinary tract symptoms, with some studies showing equivalence to common pharmacologic agents.
3 citations
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January 2017 in “Journal of cosmetology & trichology” In this clinical trial, supplementation with Lambdapil® Anti Hair Loss capsules for 6 months significantly improved hair resistance and volume in women and increased the anagen/telogen hair ratio in men, indicating enhanced hair growth compared to the placebo group.
2 citations
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April 2016 in “Más dermatología” This study found that the dietary supplement RJ-SP4AGA significantly improved hair growth and reduced hair loss in post-menopausal women with androgenetic alopecia over 16 weeks.
1 citations
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November 2021 in “British Journal of Clinical Pharmacology” This case report suggests a potential link between the intake of Serenoa repens, commonly known as Saw palmetto, and the onset of erectile dysfunction.
1 citations
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March 2014 in “Senses and Sciences” This article describes a clinical case of a 67-year-old patient with telogen effluvium treated with a supplement containing amino acids, vitamin E, iron, and Serenoa repens, but reports no new clinical findings.
March 2026 in “Planta Medica” Serenoa repens extract may help hair growth in both men and women.
January 2026 in “British Journal of Clinical Pharmacology” In this study, reports from individuals using Serenoa repens indicated a possible post-Serenoa syndrome characterized by persistent sexual and neuropsychiatric symptoms, with causality assessed as 'probable' in 54% of cases, highlighting an underrecognized safety concern that warrants further investigation.
October 2025 in “International Journal of Cosmetic Science” This study explored the effects of USPlus® DERM, a bioactive fatty acid extract from Serenoa repens, in promoting hair growth and enhancing hair follicle stem cell stemness in an ex vivo setting, showing potential for both 5‐α reductase-dependent and independent hair loss treatments.
October 2025 in “Scientific Reports” This study found that the extracts of Serenoa repens, when evaluated through chemical, biological, and in silico methods, demonstrated anti-inflammatory, pro-apoptotic, and anti-androgenic activities against prostate cancer cell lines, suggesting potential therapeutic benefits and directing future pharmaceutical development.
February 2025 in “Clinical & Experimental Dermatology and Therapies” In this randomized trial, oral supplementation with Serenoa repens, pumpkin seed extracts, and cysteine significantly improved the clinical effectiveness of topical 5% minoxidil lotion for treating androgenic alopecia in men and women compared to minoxidil alone, with both treatments being well tolerated.
December 2024 in “Egyptian Journal of Chemistry” This review highlights that Serenoa repens exhibits anti-androgenic and anti-inflammatory activities, potentially alleviating benign prostate hyperplasia symptoms, with phytosterols and fatty acids as key active constituents, while suggesting more research into additional medicinal uses and phytochemicals is needed.
September 2024 in “Journal of the American Academy of Dermatology” No specific results were reported in this abstract; it aims to explore the psychological effects of hair loss conditions like Chronic Telogen Effluvium and Androgenetic Alopecia, emphasizing the potential link between micronutrient deficiency and hair health.
September 2021 in “Elsevier eBooks” This source does not provide specific results but reviews scientific research on saw palmetto, highlighting its potential efficacy for benign prostatic hyperplasia and other men's genitourinary disorders, while noting caution for use in women with childbearing potential.
This review concludes that the global literature supports the efficacy and safety of lipidosterolic extract of Serenoa repens in treating lower urinary tract symptoms, comparable to alpha-blockers and 5α-reductase inhibitors.
December 2020 in “Biomedical Journal of Scientific and Technical Research” Serenoa repens, a natural compound, can increase hair count and help repair capillaries, making it a promising treatment for hair loss.
October 2018 in “Elsevier eBooks” This source reports that Serenoa repens may be an effective and safe natural remedy for treating benign prostatic hyperplasia, possibly working through mechanisms like apoptosis stimulation, 5-alpha-reductase inhibition, and blocking DHT receptor interactions, with minimal side effects.
September 2017 in “Zenodo (CERN European Organization for Nuclear Research)” This study suggests that a topical hydroalcoholic extract of liquorice root significantly reduced sebaceous gland size in Syrian hamsters, indicating potential for use in anti-acne therapy.
January 2009 in “DOAJ (DOAJ: Directory of Open Access Journals)” This article reviews the use of Serenoa repens for androgenetic alopecia and highlights a lack of evidence supporting its efficacy, calling for larger clinical trials.
In this experimental study, mixing temperature and rate were found to significantly influence cream's physical properties, with mixing rate affecting spreadability and temperature affecting viscosity.
The best mix of propylene glycol and sorbitol was found for a cream to prevent hair loss using saw palmetto extract.
Saw palmetto cream for hair loss works better with glycerol and sorbitol.
This study found that glycerol most significantly influenced the spreadability and initial viscosity of a saw palmetto anti-hair loss cream, while PEG 400 predominantly affected viscosity changes over time.
In this study, the researchers found that glycerol strongly influenced the physical characteristics of an anti hair loss cream containing Saw Palmetto extract, notably improving its spreadability, viscosity, and stability without causing skin irritation.