16 citations
,
May 2019 in “Hormone and Metabolic Research” This systematic review found insufficient evidence to support protective effects of selenium on polycystic ovary syndrome complications, despite some studies suggesting it may reduce insulin resistance and dyslipidemia.
16 citations
,
December 2005 in “Journal of Animal Physiology and Animal Nutrition” This study found that both low and high dietary selenium levels reduced hair growth in adult dogs, with optimal growth observed at mid-range selenium concentrations.
16 citations
,
January 1996 This review discusses selenium's role in human and animal health, its deficiency's link to diseases in China, and the need for precise geochemical control data; it reports no new findings.
15 citations
,
July 1984 in “Nutrition Research” Selenium increased in hair but not in blood after taking supplements.
15 citations
,
March 1997 in “International Journal of Dermatology” In this case report, the authors describe green hair discoloration in a patient attributed to the use of selenium sulfide.
13 citations
,
October 1960 in “Experimental Biology and Medicine” This study found that small amounts of subcutaneously injected Se75 were deposited and retained in the hair of dogs for up to 316 days.
12 citations
,
July 1964 in “Archives of Dermatology” This study found that neither a single application nor prolonged exposure to selenium sulfide had a significant effect on hair growth or rest phase percentages.
11 citations
,
January 2016 in “BMC veterinary research” This study found that urinary selenium to creatinine ratio and serum selenium concentrations quickly respond to changes in dietary selenium, making them useful biomarkers for assessing selenium status in dogs.
9 citations
,
September 1989 in “PubMed” This study observed that selenium levels were lower in Sudanese children with malnutrition compared to healthy German children, with a good correlation between selenium and glutathione peroxidase activity.
7 citations
,
March 2023 in “European Journal of Dermatology” Using Selenium Disulfide shampoo weekly helps prevent scalp dermatitis flare-ups.
5 citations
,
July 2019 in “Nutrients” This study found that boys in Mexico City with selenium intake below the recommended dietary allowance had lower odds of progressing to advanced stages of pubertal development, while no association was observed in girls.
4 citations
,
January 1989 This study found that growth affects selenium deposition in hair, nails, and other tissues of adult and weanling rats, indicating dietary and physiological factors may influence selenium levels.
4 citations
,
January 2016 in “Dermatology online journal” This report describes a case of acquired yellow hair discoloration in a 77-year-old woman, potentially caused by applying selenium sulfide after bacitracin zinc to her scalp.
2 citations
,
October 1961 in “Experimental Biology and Medicine” This study found that rabbits fed a diet deficient in Vitamin E developed severe muscular dystrophy that was not fully prevented by adding selenium, Vitamin E supplements, or natural feedstuffs, indicating other nutritional deficiencies.
2 citations
,
February 1983 in “International Journal of Cosmetic Science” This study found that both hard and soft selenium disulphide-based detergents significantly increased triglyceride levels in human hair, suggesting enhanced sebum production with reduced lipolytic activity, but showed no significant differences between their effects.
1 citations
,
August 2023 in “Journal of cosmetic dermatology (Print)” This review discusses the potential link between selenium supplementation and symptoms of chronic selenium toxicity, such as hair loss and nail dystrophy, due to excess intake leading to disruptions in hair and nail protein structure.
1 citations
,
February 2021 in “Animal feed science and technology” This study found that puppies fed organic selenium had better retention of selenium compared to those fed inorganic selenium, with no significant difference in coat quality or hair growth.
1 citations
,
March 2020 in “̒Ulūm-i dārūyī” This study found that one month of selenium supplementation improved liver and kidney function biomarkers and reduced severe hair loss in patients with beta-thalassemia major.
1 citations
,
September 2019 in “Journal of cosmetic dermatology” This study found no significant difference in serum levels of lead and selenium between patients with premature hair graying and those without it.
1 citations
,
January 2018 in “Molecular and integrative toxicology” This review discusses the dual role of selenium in human health, highlighting both the dangers of deficiency and potential toxicity from over-supplementation, without presenting new clinical results.
1 citations
,
June 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that an Enterobacter isolate demonstrated high resistance to selenate and effective sorption capacity, suggesting potential for bioremediation of selenium-contaminated environments.
1 citations
,
June 2009 in “Integrated Environmental Assessment and Management” This article discusses the dual nature of selenium, highlighting its essential metabolic roles and potential toxicity at high doses, and reports no new experimental findings.
August 2026 in “Frontiers in Pharmacology” In this case report, a 27-year-old woman experienced severe multisystem toxicity, including toxic encephalopathy, vision, and hearing loss, after ingesting selenium at occupationally high doses, suggesting such exposure can lead to previously unreported effects of vision and hearing impairment.
February 2026 in “Pakistan Veterinary Journal” In this study of White cashmere goat ewes and their offspring in Tibet, selenium and vitamin E supplementation improved antioxidant capacity and serum biochemical indices and enhanced secondary hair follicle development in lambs, but did not significantly alter fecal microbiota composition.
January 2026 in “SHILAP Revista de lepidopterología” In this study, researchers highlight the importance of correcting selenium and zinc deficiencies as part of a comprehensive management strategy for patients with autoimmune thyroiditis complicated by alopecia, as these elements play key roles in thyroid hormone biosynthesis and hair follicle function.
September 2025 in “Clinical Toxicology” In this investigation, acute alopecia was linked to selenium-contaminated wheat in rural Maharashtra, India, following reports of sudden hair loss in 18 villages, with evaluations conducted in Machindrakhed and Bhondgaon.
This research highlights selenium's critical roles in various biological processes and underscores the potential health impacts of both its deficiency and excess, including increased mortality risk, poor immune function, and neurological issues.
In this study, women with acute telogen effluvium taking the Hair’InsideTM supplement for 84 days showed significant improvements in hair regrowth, shedding, brightness, and volume compared to placebo, with no reported adverse effects.
July 2025 in “International Journal of Pharmaceutical Sciences Review and Research” This review investigates how selenium, a trace element found in wheat, may impact hair health by examining its biochemical role in hair follicle biology and its potential therapeutic and toxicological effects.
August 2024 in “Journal of Cosmetic Dermatology” This study investigates differences in nutritional status, vitamin, and mineral levels between individuals with telogen effluvium and a control group, aiming to understand the nutritional factors involved in this condition.