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    Glossary Selective Estrogen Receptor Modulators

    modulate estrogen effects in different tissues selectively

    Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor. They can either block or activate estrogen's effects in different tissues, depending on the specific SERM and the tissue type. For example, they might block estrogen's action in breast tissue to reduce the risk of breast cancer, while activating it in bone tissue to help maintain bone density.

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    1. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators Climacteric · 2007 · 67 citations
    2. The Effects of Estradiol, Androgens and the Selective Estrogen Modulators: Ospemifene, Raloxifene and Tamoxifen on Explant Cultures of Human Breast Tissue UTUPub (University of Turku) · 2013
    3. EP1410 - ECE_1202 - Individualized endocrine care in non-binary individuals: efficacy, safety, and long-term outcomes of microdosing and selective hormone modulators European Journal of Endocrinology · 2026
    4. Biology of estrogens in skin: implications for skin aging Experimental Dermatology · 2005 · 187 citations
    5. The role of estrogen in cutaneous ageing and repair Maturitas · 2017 · 158 citations
    6. Estrogens and aging skin Dermato-endocrinology · 2013 · 150 citations
    7. Effect of estrogens on skin aging and the potential role of SERMs Clinical Interventions in Aging · 2007 · 120 citations
    8. Anatomical and Dermatologic Manifestations of Estrogen Deficiency in Postmenopausal Women: A Systematic Review Pakistan Journal of Health Sciences · 2025
    9. MANAGING ESTROGEN-DEFICIENT SKIN: A NARRATIVE REVIEW ON THE ROLE OF HRT AND EMERGING ESTROGEN-MODULATING THERAPIES International Journal of Innovative Technologies in Social Science · 2025
    10. Emerging medication for the treatment of male hypogonadism Expert Opinion on Emerging Drugs · 2012 · 77 citations
    11. Menopause and aging, quality of life and sexuality Climacteric · 2007 · 55 citations
    12. Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death Frontiers in Cellular Neuroscience · 2015 · 34 citations
    13. Consequences of Anabolic-Androgenic Steroid Abuse in Males; Sexual and Reproductive Perspective ˜The œworld journal of men's health · 2021 · 19 citations
    14. Young coconut juice can accelerate the healing process of cutaneous wounds BMC Complementary and Alternative Medicine · 2012 · 19 citations
    15. Chemoprävention des Prostatakarzinoms - Ein Plädoyer Aktuelle Urologie · 2012 · 1 citations
    16. Persistent Gynecomastia due to Short-term Low-dose Finasteride for Androgenetic Alopecia JCEM case reports · 2024
    17. Trazodone associated with Clomiphene a proposal treatment for post finasteride syndrome Magna Scientia Advanced Research and Reviews · 2023
    18. Tamoxifen-associated hirsutism: an unusual side effect in a 5-year-old girl with McCune-Albright syndrome 2015
    19. Androgen receptor: A promising therapeutic target in breast cancer Critical Reviews in Clinical Laboratory Sciences · 2019 · 21 citations
    20. New approaches to the treatment of osteoporosis Current Opinion in Chemical Biology · 2000 · 28 citations
    21. Chapter 17. Selective androgen receptor modulators (SARMs) Annual Reports in Medicinal Chemistry · 2001 · 18 citations
    22. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia Journal of Nutrition Health & Aging · 2013 · 211 citations
    23. Hepatotoxicity Associated with Anabolic Androgenic Steroids and Selective Androgen Receptor Modulators: A Literature Review Medical Science · 2025
    24. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    25. Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer Cancer research · 2013 · 2 citations
    26. Selective androgen receptor modulators: a critical appraisal Frontiers in Endocrinology · 2025 · 2 citations
    27. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    28. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands 2009 · 36 citations
    29. The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial Journal of cachexia, sarcopenia and muscle · 2011 · 306 citations
    30. Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus Journal of Endocrinology · 2019 · 19 citations