1 citations
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July 2023 in “Psychoneuroendocrinology” This study found that hair cortisol concentration is consistently associated with salivary cortisol output throughout the day, making it a potential reliable biomarker of long-term cortisol secretion.
August 2016 in “Psychoneuroendocrinology” 19 citations
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June 2020 in “General and comparative endocrinology” This study found that hair cortisol concentration is a promising stress indicator in cattle but not in pigs, where external factors and lower cortisol response may interfere with its validity.
In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.
January 2017 in “Qucosa (Saxon State and University Library Dresden)” This study found that plasma protein binding significantly contributes to the shifts in glucocorticosteroid concentration ratios among blood, saliva, and hair, challenging prior assumptions about enzyme inactivation as the main factor.
April 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Hair cortisol is a reliable long-term stress marker during pregnancy.
567 citations
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October 2007 in “Clinical and investigative medicine” This study described a new assay for measuring cortisol in hair and found it may serve as a useful biomarker for long-term cortisol exposure, correlating with 24-hour urine cortisol levels in non-obese subjects.
80 citations
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January 2011 in “Clinical Chemistry and Laboratory Medicine (CCLM)” This study confirmed that the diffusion of cortisol from blood is a biologically endogenous source of hair cortisol, correlating significantly with salivary cortisol levels in healthy humans.
101 citations
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January 2014 in “Journal of Visualized Experiments” This study validated a method for measuring cortisol levels in hair, which may serve as a biomarker for chronic stress in both humans and various animals.
May 2012 in “Neurotoxicology and Teratology” Hair cortisol can be a reliable way to measure long-term stress.
189 citations
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January 2014 in “Journal of Visualized Experiments” This study developed and validated a method for extracting cortisol from human and animal hair, suggesting its potential as a biomarker for assessing chronic stress exposure.
49 citations
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April 2016 in “International journal of molecular sciences” This study found that shift nurses exhibited lower circadian variations compared to daytime nurses, indicating an adjustment of their biological clocks to continuous shift schedules.
9 citations
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April 2016 in “Clinical Endocrinology” This study suggests that measuring scalp hair 17-hydroxyprogesterone and androstenedione concentrations can be a promising tool for monitoring treatment in children with congenital adrenal hyperplasia.
1 citations
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January 2013 in “Journal of S C C J” This study suggests that scalp massage may reduce stress, as indicated by decreased salivary cortisol and increased secretory immunoglobulin A, and improve comfort by reducing physical fatigue and negative emotions.
This study is designed to explore how circadian rhythms are affected by obesity and mental health conditions, such as schizophrenia and bipolar disorder, using biological and lifestyle data from independently living adults.
13 citations
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January 2025 in “Lab on a Chip” This review discusses recent developments in capillary microfluidic wearables for non-invasive, continuous biofluid monitoring, highlighting advances in device design, electrochemical and optical biosensing, and the challenges of clinical validation and scalable manufacturing.
January 2025 in “JCEM Case Reports” In this case report, researchers described a patient with Cushing's Disease exhibiting no detectable mass, where Metyrapone therapy was effectively used to manage symptoms, suggesting a treatment option for similar diagnostic challenges.
May 2023 in “Animal Reproduction Update” This article reviews the use of hair cortisol concentration as a biomarker to assess long-term stress in both animals and humans, but it reports no new experimental results.
23 citations
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August 2017 in “Scientific Reports” Darker hair may lead to higher cortisol readings, suggesting a need to adjust for hair color in studies.
2 citations
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December 2021 in “Scientific reports” In this study, scalp hair sweating was a significant predictor of hair cortisol levels in healthy adults, while BMI and perceived stress, although associated, did not significantly predict cortisol levels.
January 2023 in “Research Square (Research Square)” This study suggests that measuring cortisol levels in hair may serve as a useful biomarker for assessing mood in individuals with bipolar disorder over recent months.
3 citations
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June 2021 in “Journal of affective disorders” This study suggests that hair cortisol and cortisone may moderate the relationship between work stress and depressive symptoms in Chinese fishermen, although their mechanisms differ.
2 citations
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June 2022 in “Scientific reports” This study found that women with PCOS had significantly higher hair cortisol concentrations, suggesting hyperactivation of the HPA axis may affect metabolic and inflammatory markers in those with elevated cortisol levels.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this review, researchers examined the concentration of cortisol in scalp hair of individuals with alopecia areata to explore its relationship with disease variables, as cortisol in hair can indicate chronic stress, which may impact alopecia areata pathogenesis.
501 citations
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October 2008 in “Psychoneuroendocrinology” This study suggests that cortisol measured in human hair can effectively reflect increased production for up to six months, but its retrospective accuracy may be limited due to rapid decline in levels.
April 2026 in “Al-Kufa University Journal for Biology” In this animal study, finasteride was found to significantly lower cortisol and increase testosterone levels in female rats, indicating its broader impact on endocrine regulation by altering adrenal and gonadal hormones.
August 2019 in “Journal of archaeological science: Reports/Journal of archaeological science: reports” This study demonstrated that cortisol, estradiol, and testosterone are preserved in archaeological human hair, allowing for the analysis of ancient stress and reproductive hormone patterns.
21 citations
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April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics” This study suggests that gel containing OSF3 loaded in niosomes offers high transfollicular penetration for topical anti-androgenic alopecia treatment with minimal systemic effect.
April 2026 in “Frontiers in Veterinary Science” This study observed that in privately owned, intact cats, male cats exhibited significantly higher long-term hair cortisol concentrations compared to females, while environmental and behavioral factors did not significantly impact cortisol levels, suggesting individual traits may influence stress markers more than external factors.
118 citations
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October 2014 in “Journal of Dairy Science” This study found that in lactating Holstein cows, hair from the tail switch, which grows faster and is more sensitive to cortisol changes, is ideal for measuring hair cortisol levels.