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Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

Men with less sun-sensitive skin have lower PSA levels, while men with more sun-sensitive skin have higher PSA levels.

Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.

Bariatric surgery patients need careful before and after surgery care for safety and long-term health.

New micelle solutions greatly improve skin delivery of certain antifungal drugs.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Asian immigrant mothers in Leicestershire need better obstetric care to reduce higher perinatal mortality risks.

Taking metformin with intense-pulsed-light therapy improves hair removal for people with PCOS.

A low-starch/low-dairy diet may help overweight women with PCOS lose weight and improve metabolism, but more research is needed.

Eating less and exercising more, with personalized diet plans and realistic goals, can lead to weight loss and better health, but more research is needed for long-term success.

Intramuscular corticosteroids are effective and safe for severe alopecia areata, with most patients regrowing hair, but nearly half may relapse.

A pet ferret had a serious infection from Mycobacterium xenopi, which can spread to humans.

Careful planning and accurate diagnosis are crucial for successful hair restoration surgery.

Busulfan/cyclophosphamide and total bone irradiation are equally effective for AML transplants.

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

Different prostate cancer treatments have similar risks of secondary cancers and related mortality when considering patient age and smoking history.

Microneedling with topical dutasteride improves hair growth in men with hair loss and is safe to use.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Peptide hydrogels heal burn wounds faster and better than standard dressings.

Testosterone's muscle-building effects do not require its conversion to DHT.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.