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    Glossary Regenerative Cell Matrix

    biological scaffold aiding tissue repair and cell growth

    A Regenerative Cell Matrix (RCM) is a biological scaffold that supports the growth and differentiation of cells, aiding in tissue repair and regeneration. It is often used in medical treatments to promote healing in damaged tissues, including skin, muscles, and even hair follicles, by providing a conducive environment for cell proliferation and tissue integration.

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    1. A regenerative stem cell-derived matrix accelerates functional dermal wound repair in a preclinical diabetic model 2026
    2. Effect of porcine acellular dermal matrix on the expression of stromal cell-derived factor-1 and Wnt3a/β-catenin signaling pathway in mice hair follicle regeneration Chin J Injury Repair and Wound Healing(Electronic Edition) · 2019
    3. Matrigel uses in cell biology and for the identification of thymosin β4, a mediator of tissue regeneration Applied Biological Chemistry · 2018 · 15 citations
    4. Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration Dermatologic Surgery · 2017 · 1 citations
    5. Modulating the stem cell niche for tissue regeneration Nature Biotechnology · 2014 · 480 citations
    6. A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(l-lactide-<i>co</i>-caprolactone) for Endothelial Cells Delivery and Skin Wound Repair ACS Biomaterials Science & Engineering · 2018 · 16 citations
    7. Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis Acta Biomaterialia · 2013 · 65 citations
    8. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021 · 74 citations
    9. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    10. Programmable viscoelastic hydrogels exhibit antimicrobial and regenerative properties to promote cell migration, wound healing, and tissue remodeling Microsystems & Nanoengineering · 2026
    11. Extracellular matrix‐based combination scaffold for guided regeneration of large‐area full‐thickness rabbit burn wounds upon a single application Journal of biomedical materials research. Part B, Applied biomaterials · 2021 · 3 citations
    12. The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility Biomaterials · 2009 · 44 citations
    13. Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies International Journal of Molecular Sciences · 2017 · 269 citations
    14. A novel cell-free regenerative therapy for hair loss: human fetal cartilage progenitor cell secretome Biomaterials · 2025
    15. iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration PLOS ONE · 2016 · 19 citations
    16. Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin International journal of molecular sciences · 2023 · 2 citations
    17. Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration Nature Communications · 2022
    18. Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 1 citations
    19. Regenerative Medicine of Epidermal Structures Elsevier eBooks · 2012
    20. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair Stem Cell Reviews and Reports · 2016 · 24 citations
    21. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Biomaterials · 2007 · 309 citations
    22. Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair Stem Cells · 2013 · 50 citations
    23. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging Clinical Cosmetic and Investigational Dermatology · 2023 · 22 citations
    24. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    25. Wound Healing: A Paradigm for Regeneration Mayo Clinic Proceedings · 2013 · 64 citations
    26. Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair BMC Biotechnology · 2024 · 5 citations
    27. Divergent molecular signatures of regeneration and fibrosis during wound repair bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 3 citations
    28. Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering Nanomaterials · 2024 · 1 citations
    29. A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration Stem Cell Research & Therapy · 2021 · 19 citations
    30. The Therapeutic Role of ADSC-EVs in Skin Regeneration Frontiers in Medicine · 2022 · 7 citations