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GlossaryRandomized Controlled Trials

scientific studies comparing treatments by randomly assigning participants

Randomized Controlled Trials (RCTs) are scientific studies designed to test the effectiveness of medical treatments or interventions by randomly assigning participants to either a treatment group or a control group. This randomization helps eliminate bias, ensuring that any differences observed between the groups can be attributed to the treatment itself rather than other factors. RCTs are considered the gold standard in clinical research for establishing causality and assessing the efficacy and safety of new therapies.

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research A Randomized, Placebo-Controlled Trial of 1% Topical Minoxidil Solution in the Treatment of Androgenetic Alopecia in Japanese Women

10 citations, January 2007 in “PubMed”

1% topical minoxidil solution significantly improved hair growth in Japanese women with androgenetic alopecia, with no major side effects.

research Randomized Controlled Trial on a PRP-Like Cosmetic with Biomimetic Peptides for the Treatment of Alopecia Areata

8 citations, December 2018 in “Journal of Dermatological Treatment”

The PRP-like cosmetic with biomimetic peptides is potentially effective and safe for treating alopecia areata.

Response to Baricitinib in the Treatment of Patients with Early and Late Onset Alopecia Areata in the Phase 2 Portion of BRAVE-AA1 Randomized Controlled Trial

research Response to Baricitinib in the Treatment of Patients with Early and Late Onset Alopecia Areata in the Phase 2 Portion of BRAVE-AA1 Randomized Controlled Trial

1 citations, August 2021 in “Journal of The American Academy of Dermatology”

Baricitinib was effective in treating both early and late onset alopecia areata.

Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial

research Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial

August 2023 in “Expert Review of Clinical Pharmacology”

Cetirizine lotion can effectively treat female pattern hair loss.

Photobiomodulation Therapy for the Management of Chemotherapy-Induced Alopecia: Preliminary Results of a Randomized, Controlled Trial

research Photobiomodulation Therapy for the Management of Chemotherapy-Induced Alopecia: Preliminary Results of a Randomized, Controlled Trial

May 2022 in “Annals of Oncology”

Photobiomodulation therapy may speed up hair regrowth after chemotherapy in the short term.

research Comparing the Efficacy of Mesotherapy to Topical Minoxidil in the Treatment of Female Pattern Hair Loss Using Ultrasound Biomicroscopy: A Randomized Controlled Trial

March 2019 in “PubMed”

Mesotherapy is more effective and preferred for female hair loss than topical minoxidil.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations, March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial

33 citations, July 2020 in “Journal of The American Academy of Dermatology”

PRP treatment improves hair density and thickness for alopecia, but needs more research.

research The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial

18 citations, July 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research A Randomized Controlled Trial Comparing Total Glucosides of Paeony Capsule and Compound Glycyrrhizin Tablet for Alopecia Areata

18 citations, August 2012 in “Chinese journal of integrative medicine/Chinese Journal of Integrative Medicine”

Both treatments for alopecia areata are equally effective and safe.

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

11 citations, January 2019 in “International Journal of Trichology”

Mesotherapy is not significantly better than minoxidil for treating male hair loss.

research Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination, and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial

11 citations, January 2017 in “Journal of research in pharmacy practice”

The combination of zinc sulfate and calcium pantothenate effectively controls early-stage hair loss.

The Effect of Curcumin on Metabolic Parameters and Androgen Level in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial

research The Effect of Curcumin on Metabolic Parameters and Androgen Level in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial

2 citations, February 2023 in “BMC endocrine disorders”

Curcumin improved some metabolic factors in women with PCOS but did not affect cholesterol, insulin, or testosterone levels.

Comparative Study of the Efficacy and Safety of Topical Minoxidil 2% Versus Topical Bimatoprost 0.01% Versus Topical Bimatoprost 0.03% in Treatment of Eyebrow Hypotrichosis: A Randomized Controlled Trial

research Comparative Study of the Efficacy and Safety of Topical Minoxidil 2% Versus Topical Bimatoprost 0.01% Versus Topical Bimatoprost 0.03% in Treatment of Eyebrow Hypotrichosis: A Randomized Controlled Trial

1 citations, July 2023 in “Archives of dermatological research”

Bimatoprost 0.03% is as effective as minoxidil 2% for eyebrow growth.

P110 Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

research P110 Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

June 2024 in “British Journal of Dermatology”

PRP with topical minoxidil is the most effective treatment for increasing hair density in androgenetic alopecia.

Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

research Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

June 2024 in “British Journal of Dermatology”

Combining PRP with topical minoxidil is the most effective for increasing hair density in male pattern baldness.

research The Effect of an Oral Product Containing Amla Fruit on Female Androgenetic Alopecia: A Randomized Controlled Trial

July 2023 in “Journal of Ethnopharmacology”

Amla fruit syrup improved hair growth and satisfaction in women with hair loss without significant side effects.

Evaluation of Platelet-Rich Plasma Plus Basic Fibroblast Growth Factor Combined With Minoxidil in the Treatment of Androgenetic Alopecia: A Randomized Controlled Trial

research Evaluation of Platelet-Rich Plasma Plus Basic Fibroblast Growth Factor Combined With Minoxidil in the Treatment of Androgenetic Alopecia: A Randomized Controlled Trial

May 2023 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma, basic fibroblast growth factor, and minoxidil together significantly increases hair count and growth rate in people with hair loss.

research Effect of a Medicinal and Edible Decoction YH0618 on Chemotherapy-Induced Dermatologic Toxicity: A Randomized Controlled Trial

January 2021 in “Annals of translational medicine”

YH0618 helped reduce skin and nail problems and fatigue in chemotherapy patients.

research Evaluating the Combined Efficacy of Oral Isotretinoin and Topical Tacrolimus Versus Oral Finasteride and Topical Tacrolimus in Frontal Fibrosing Alopecia: A Randomized Controlled Trial

July 2022 in “Journal of Cosmetic Dermatology”

Isotretinoin with tacrolimus may be more effective short-term for treating frontal fibrosing alopecia than finasteride with tacrolimus.

Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

research Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

3 citations, July 2019 in “Supportive Care in Cancer”

The lotion CG428 did not show effectiveness in treating permanent hair loss in breast cancer survivors.

Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial

research Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial

42 citations, July 2021 in “Frontiers in Medicine”

Proxalutamide significantly lowered hospital admissions for male COVID-19 patients compared to a placebo.

research Antagonism of NMDA Receptors as a Potential Treatment for Down Syndrome: A Pilot Randomized Controlled Trial

81 citations, July 2012 in “Translational Psychiatry”

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

research The Effects of Minoxidil, 1% Pyrithione Zinc, and a Combination of Both on Hair Density: A Randomized Controlled Trial

57 citations, August 2003 in “British Journal of Dermatology”

Minoxidil and pyrithione zinc combo most effectively increases hair density.

Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial

research Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial

26 citations, March 2015 in “American journal of clinical dermatology”

Topical clobetasol is recommended over mycophenolate mofetil for treating Lichen Planopilaris due to better safety and patient satisfaction.

Oral Isotretinoin Combined with Topical Clobetasol 0.05% and Tacrolimus 0.1% for the Treatment of Frontal Fibrosing Alopecia: A Randomized Controlled Trial

research Oral Isotretinoin Combined with Topical Clobetasol 0.05% and Tacrolimus 0.1% for the Treatment of Frontal Fibrosing Alopecia: A Randomized Controlled Trial

11 citations, April 2020 in “Journal of Dermatological Treatment”

Taking oral isotretinoin with creams worked better for treating a type of hair loss than creams alone.

Effect of Phlebotomy Versus Oral Contraceptives Containing Cyproterone Acetate on Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

research Effect of Phlebotomy Versus Oral Contraceptives Containing Cyproterone Acetate on Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

7 citations, August 2019 in “Journal of Ovarian Research”

Blood removal and birth control pills both helped with hormone levels in women with PCOS, but birth control was better for regular periods and blood removal had fewer side effects.

Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

1 citations, April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Efficacy of Baricitinib in Adults with Alopecia Areata: Patients’ Perspectives on Hair Regrowth from Two Phase III Randomized Controlled Trials (BRAVE-AA1 and BRAVE-AA2)

research Efficacy of Baricitinib in Adults with Alopecia Areata: Patients’ Perspectives on Hair Regrowth from Two Phase III Randomized Controlled Trials (BRAVE-AA1 and BRAVE-AA2)

1 citations, July 2022 in “British Journal of Dermatology”

Baricitinib was effective in treating hair loss in adults with alopecia areata according to patient feedback.

Topical 5% Minoxidil Versus Combined Erbium YAG Laser and Topical 5% Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

research Topical 5% Minoxidil Versus Combined Erbium YAG Laser and Topical 5% Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

August 2023 in “Journal of Cosmetic Dermatology”

Using a laser with minoxidil was more effective for hair loss than minoxidil alone.