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    Glossary Protein

    vital macromolecule composed of amino acids essential for life

    Protein is a vital macromolecule made up of amino acids, which are the building blocks of life. It plays a crucial role in the structure, function, and regulation of the body's tissues and organs, including hair growth and repair. Proteins are essential for various biological processes, such as enzyme activity, immune response, and cellular communication.

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    1. Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion Journal of Cell Science · 1999 · 135 citations
    2. iε-(γ<sup>-Glutamyl</sup>) lysine cross-linkage in citrulline-containing protein fractions from hair Biochemistry · 1971 · 125 citations
    3. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    4. A Nonredundant Human Protein Chip for Antibody Screening and Serum Profiling Molecular & cellular proteomics · 2003 · 117 citations
    5. Clinical Use of a Protein-Sparing Modified Fast JAMA · 1978 · 104 citations
    6. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    7. Protein Kinase C as a Therapeutic Target Clinical Cancer Research · 2006 · 87 citations
    8. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    9. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    10. Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways The Journal of Immunology · 2003 · 74 citations
    11. Protein Microarrays BioTechniques · 2006 · 73 citations
    12. Cosmeceuticals: peptides, proteins, and growth factors Journal of Cosmetic Dermatology · 2016 · 67 citations
    13. Protein-phosphatase inhibitors block root hair growth and alter cortical cell shape of Arabidopsis roots Planta · 1994 · 61 citations
    14. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    15. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    16. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate Vitamins and hormones · 1976 · 59 citations
    17. Regulation of stem cell function by protein ubiquitylation EMBO Reports · 2014 · 55 citations
    18. Characterization of the Human Hair Keratin–Associated Protein 2 (KRTAP2) Gene Family Journal of Investigative Dermatology · 2012 · 52 citations
    19. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    20. Morphological Changes in Human Scalp Hair Roots during Deprivation of Protein Science · 1967 · 47 citations
    21. Protein deprivation: comparative response of hair roots, serum protein, and urinary nitrogen American Journal of Clinical Nutrition · 1971 · 46 citations
    22. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    23. Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation Small · 2022 · 40 citations
    24. Protein and sulphur amino acid nutrition of hair fibre-producing Angora and Cashmere goats Livestock production science · 2000 · 38 citations
    25. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes Human Molecular Genetics · 2010 · 37 citations
    26. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    27. Multiplex matrix network analysis of protein complexes in the human TCR signalosome Science Signaling · 2016 · 32 citations
    28. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000 · 32 citations
    29. Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter 2019 · 30 citations
    30. Protein disulphide isomerase-mediated grafting of cysteine-containing peptides onto over-bleached hair Biocatalysis and biotransformation · 2011 · 28 citations