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    Glossary Progesterone

    hormone regulating menstrual cycle and supporting early pregnancy

    Progesterone is a hormone produced mainly in the ovaries after ovulation and plays a crucial role in regulating the menstrual cycle and maintaining the early stages of pregnancy. It helps prepare the uterine lining for a fertilized egg to implant and supports early pregnancy by preventing muscle contractions in the uterus that could cause the body to reject the egg.

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    1. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002 · 269 citations
    2. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004 · 180 citations
    3. Anxiolytic activity of progesterone in progesterone receptor knockout mice Neuropharmacology · 2004 · 151 citations
    4. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective Journal of Neurobiology · 2006 · 123 citations
    5. Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone) The Journal of Clinical Endocrinology & Metabolism · 1975 · 96 citations
    6. Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice Hippocampus · 2009 · 85 citations
    7. Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation European Journal of Neuroscience · 2006 · 83 citations
    8. Estrus, ovulation, and serum progesterone, estradiol, and LH concentrations in mares after an increased photoperiod during winter. PubMed · 1977 · 83 citations
    9. Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility Pharmacology Biochemistry and Behavior · 2007 · 60 citations
    10. Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. PubMed · 1999 · 48 citations
    11. Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride Journal of Neurochemistry · 2002 · 47 citations
    12. Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice Brain Research · 2005 · 35 citations
    13. Profile of the progesterone derivative chlormadinone acetate — Pharmocodynamic properties and therapeutic applications Contraception · 2009 · 33 citations
    14. Progesterone Pretreatment Enhances Serotonin-Stimulated BDNF Gene Expression in Rat C6 Glioma Cells Through Production of 5α-Reduced Neurosteroids Journal of Molecular Neuroscience · 2008 · 33 citations
    15. Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy Annals of Neurology · 2003 · 30 citations
    16. Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus European Journal of Neuroscience · 2009 · 28 citations
    17. Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats European Journal of Pharmacology · 2007 · 27 citations
    18. Estrogen and Progesterone Receptors in Androgenic Alopecia Versus Alopecia Areata American Journal of Dermatopathology · 1998 · 27 citations
    19. Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling Neuroscience · 2013 · 26 citations
    20. Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis Epilepsy & Behavior · 2012 · 26 citations
    21. Progesterone Inhibits the Growth of Human Neuroblastoma: In Vitro and In Vivo Evidence Molecular Medicine · 2011 · 26 citations
    22. Changes in expression of the δ subunit of the GABA<sub>A</sub>receptor and in receptor function induced by progesterone exposure and withdrawal Journal of Neurochemistry · 2006 · 25 citations
    23. Estrus, Ovulation, and Serum Progesterone, Estradiol, and LH Concentrations in Mares After an Increased Photoperiod During Winter American Journal of Veterinary Research · 1977 · 25 citations
    24. Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy Pharmacology, Biochemistry and Behavior · 2003 · 23 citations
    25. New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors. Chemical & Pharmaceutical Bulletin · 2001 · 22 citations
    26. Sex and estrous cycle influence diazepam effects on anxiety and memory: Possible role of progesterone Progress in Neuro-Psychopharmacology and Biological Psychiatry · 2016 · 21 citations
    27. Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2015 · 21 citations
    28. Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males BMC Neuroscience · 2019 · 19 citations
    29. Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position Steroids · 1999 · 19 citations
    30. Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors Steroids · 2010 · 19 citations