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    Glossary Planar Cell Polarity

    coordinated orientation of cells within tissue plane

    Planar Cell Polarity (PCP) refers to the coordinated orientation of cells along a tissue plane, rather than just up and down. This is crucial for various biological processes, such as the uniform direction of hair growth on the skin or the proper alignment of cells in the inner ear for hearing.

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    1. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    2. 236 Wnt/planar cell polarity impairment and the genetics of yellow nail syndrome Journal of Investigative Dermatology · 2024
    3. Functional redundancy of <i>Frizzled 3</i> and <i>Frizzled 6</i> in planar cell polarity control of mouse hair follicles Development · 2018 · 24 citations
    4. Region-specific reversal of epidermal planar polarity in the <i>rosette</i> fancy mouse Development · 2023 · 2 citations
    5. Co-opting Developmental Signaling Pathways to Promote Wound Healing Recent clinical techniques, results, and research in wounds · 2018 · 1 citations
    6. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009 · 92 citations
    7. Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development Development · 2022 · 7 citations
    8. Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems The International Journal of Developmental Biology · 2023 · 21 citations
    9. Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns Developmental Biology · 2017 · 33 citations
    10. Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity Frontiers in cell and developmental biology · 2023 · 7 citations
    11. When whorls collide: the development of hair patterns in frizzled 6 mutant mice Development · 2010 · 55 citations
    12. Cell Polarization Defects in Early Heart Development Circulation Research · 2007 · 9 citations
    13. Gene Expression During Drosophila Wing Morphogenesis and Differentiation Genetics · 2005 · 57 citations
    14. Molecular mechanisms of asymmetric divisions in mammary stem cells EMBO Reports · 2016 · 79 citations
    15. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    16. Developmental Mechanisms Controlling Cell Fate, Evolution of Elsevier eBooks · 2016
    17. The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine Journal of Cellular Physiology · 2017 · 89 citations
    18. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    19. The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size Nature Communications · 2025 · 1 citations
    20. Wnt signaling induces epithelial differentiation during cutaneous wound healing Organogenesis · 2015 · 66 citations
    21. Are hair follicle stem cells promising candidates for wound healing? Expert Opinion on Biological Therapy · 2018 · 18 citations
    22. Comparative transcriptomic analysis of dermal wound healing reveals de novo skeletal muscle regeneration in Acomys cahirinus PLOS ONE · 2019 · 24 citations
    23. Biology of Human Hair: Know Your Hair to Control It 2010 · 13 citations
    24. Barley disease susceptibility factor RACB acts in epidermal cell polarity and positioning of the nucleus Journal of experimental botany · 2016 · 41 citations
    25. Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway Oncotarget · 2017 · 11 citations
    26. Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling EMBO journal · 2021 · 5 citations
    27. Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial Preprints.org · 2026
    28. Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration PloS one · 2016 · 21 citations
    29. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 32 citations
    30. Hair curvature: a natural dialectic and review 2014 · 28 citations