July 2026 in “International Journal of Drug Delivery Technology” This study found that a combination of curcumin and piperine demonstrated moderate antioxidant activity, negligible cytotoxicity, and significant potential for promoting hair regrowth in rat models of alopecia, suggesting it could be a safe and effective natural alternative for managing hair loss.
April 2024 in “Applied biological chemistry” In this study involving mice on a high-fat diet, piperine from black pepper was observed to reduce sebaceous gland size and fat accumulation, suggesting its potential in controlling hair oiliness by inhibiting adipogenesis in hair stem cells.
4 citations
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March 2022 in “Journal of cosmetic dermatology” This study concluded that a mixed preparation of piperine, capsaicin, and curcumin is effective for treating alopecia areata but is not superior to minoxidil over a short-term period.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review suggests that curcumin and piperine may offer a promising multi-target therapeutic approach for alopecia by simultaneously modulating androgenic and inflammatory pathways, though experimental and clinical validation are necessary to confirm their efficacy.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this review, researchers explored the potential of a curcumin–piperine combination in alopecia management through computational analyses, highlighting its capacity to modulate multiple pathways involved in hair follicle homeostasis, although further experimental and clinical validation is necessary to confirm its efficacy.
4 citations
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November 2024 in “Toxicology Research” In this study, researchers reported that a combined formulation of curcumin and piperine in niosomal nanoparticles shows promise as a treatment for paraquat-induced lung toxicity, potentially due to improved bioavailability and strong antioxidant properties.
![Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety](/images/assets/2ecf4eed-7dbe-4f1a-83db-739625546cdd/small/31808.jpg)
7 citations
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August 2019 in “Bioorganic & medicinal chemistry” This study identified novel 4-Amino-2H-benzo[h]chromen-2-one analogs as potent androgen receptor antagonists that show strong antiproliferative activity against prostate cancer cells, suggesting them as potential lead compounds for therapy development.
66 citations
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February 2010 in “CrystEngComm” Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
12 citations
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February 2010 in “Tetrahedron Letters” This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.
6 citations
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April 2019 in “Pesquisa Veterinária Brasileira” This article reviews the potential risks of various phytotoxins in milk for animals and humans, discussing the need for awareness and further research but providing no new findings.
5 citations
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January 2004 in “Analytical Sciences X-ray Structure Analysis Online” This structural study reports on the crystal properties of a compound used for treating alopecia, revealing different conformations and nitrogen hybridization in its piperidine rings.
4 citations
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December 2014 in “European Journal of Chemistry” This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.
66 citations
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August 2011 in “Parasitology Research” This study found that Mentha pulegium essential oil had a stronger protoscolicidal effect against Echinococcus granulosus in vitro than Mentha piperita, showing dose- and time-dependent effects.
44 citations
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January 2007 in “Biological & pharmaceutical bulletin” This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.
This source reviews various alternative therapies for vitiligo, such as khellin, 5-fluorouracil, Ginkgo biloba, and more, noting that further research is needed to confirm their effectiveness and safety.
July 2024 in “International Journal of Ayurvedic Medicine” This study used molecular docking to analyze nine compounds from the Siddha herbal formulation Kushtakudori ennai, finding that they may effectively interact with androgen receptors to hinder hair follicle shrinkage and potentially reduce hair loss, showing potential as anti-alopecia treatments.
March 2021 in “Research Square (Research Square)” This study analyzed the structure and dynamics of ketoconazole, revealing how its molecular characteristics, such as spin-lattice relaxation time and chemical shift anisotropy, are influenced by π-π stacking interactions and different carbon site environments.
Minoxidil can cause hair growth as a side effect.
December 2025 in “Molecules” This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.
April 2012 in “KSBB Journal” This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.
This invention reports piperazine derivatives as potent inhibitors of type 3 17β-hydroxysteroid dehydrogenase, suggesting potential therapeutic applications in treating prostate cancer, acne, and androgenic alopecia.
17 citations
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December 2004 in “Bioorganic & Medicinal Chemistry Letters” This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.
18 citations
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February 2023 in “PLoS ONE” This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.
4 citations
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April 2013 in “International Journal of Pharmaceutical Sciences and Drug Research” This study found that ethanol extracts from Musa paradisiaca cv. Puttabale corms have significant anthelmintic activity against Pheretima posthuma, outperforming the standard drug piperazine citrate in terms of paralysis and death times.
February 2026 in “Nature Synthesis” In this study, researchers introduced a visible-light-mediated intramolecular cycloaddition method that selectively forms 6-azabicyclo[3.1.1]heptanes, suggesting these structures could offer promising new scaffolds for drug discovery and medicinal chemistry.
1 citations
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October 2017 in “Food Additives & Contaminants: Part A” This study identified a new minoxidil analogue called triaminodil in an illegal hair-growth supplement, but no data on its chemical, toxicological, or pharmacological properties are available yet.
October 2015 in “Elsevier eBooks” Minoxidil is effective for hair growth and safe for long-term use.
37 citations
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April 1979 in “The Journal of Clinical Pharmacology” Minoxidil effectively controls blood pressure but side effects may limit its use.
December 2025 in “Biomolecules” In this study, the synthesis and testing of new pyrroloquinoline derivatives identified compound 7p, which showed low micromolar cytotoxic activity against MCF-7 and HeLa cells, highlighting its potential for development into a potent anticancer agent.
October 2015 in “Elsevier eBooks” Chewing betel nut may increase the risk of type 2 diabetes, and saw palmetto can improve urinary symptoms in BPH with fewer side effects but may cause bleeding and allergic reactions.