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    Did you mean PI3K/AKT pathway?
    Glossary PI3K/AKT pathway

    regulates cell growth, survival, and metabolism

    The PI3K/AKT pathway is a critical cell signaling pathway that helps regulate various cellular processes, including growth, survival, and metabolism. When activated, it can promote cell proliferation and inhibit programmed cell death (apoptosis), making it significant in contexts like cancer research and treatment, as well as in understanding hair growth and conditions like alopecia.

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    1. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    2. Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway Stem Cell Research & Therapy · 2022 · 26 citations
    3. The regulation mechanism of different hair types in inner Mongolia cashmere goat based on PI3K-AKT pathway and <i>FGF21</i> Journal of Animal Science · 2022 · 22 citations
    4. Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads Journal of Bioscience and Bioengineering · 2022 · 12 citations
    5. Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway Journal of Applied Biomedicine · 2013 · 11 citations
    6. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    7. LncRNA RP11-818O24.3 regulates proliferation and differentiation of hair follicle stem cells by targeting FGF2/PI3K/AKT pathway PLoS ONE · 2025 · 1 citations
    8. CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways Cell Death and Disease · 2025
    9. LncRNA RP11-818024.3 Promotes Hair-Follicle Recovery Via FGF2-PI3K/Akt Signal Pathway SSRN Electronic Journal · 2022
    10. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026
    11. Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia PLOS ONE · 2023
    12. Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits Animal nutrition · 2021 · 10 citations
    13. PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration Stem Cell Research & Therapy · 2020 · 30 citations
    14. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    15. Dental pulp stem cell exosomes promote angiogenesis via the PI3K/Akt signaling pathway to treat androgenetic alopecia Stem Cell Research & Therapy · 2026
    16. Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway Journal of Ovarian Research · 2025
    17. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021 · 30 citations
    18. Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway Frontiers in Pharmacology · 2024 · 3 citations
    19. Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model Journal of Biomedical Nanotechnology · 2022
    20. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway Life Sciences · 2019 · 28 citations
    21. Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells Biomolecules & Therapeutics · 2020 · 14 citations
    22. BFNB Enhances Hair Growth in C57BL/6 Mice through the Induction of EGF and FGF7 Factors and the PI3K-AKT-β-Catenin Pathway International Journal of Molecular Sciences · 2023 · 2 citations
    23. Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway Stem Cell Research & Therapy · 2025
    24. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    25. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    26. The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota Current Issues in Molecular Biology · 2025
    27. Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling International Journal of Molecular Sciences · 2024 · 12 citations
    28. LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway Cytotechnology · 2024 · 4 citations
    29. Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by Hedera helix L. saponins: a new approach for the treatment of Pseudomonas aeruginosa-induced bacterial keratitis Natural Products and Bioprospecting · 2025 · 1 citations
    30. Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway Scientific Reports · 2024 · 9 citations