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Glossary Peripheral Neuropathy

damage to peripheral nerves causing numbness, tingling, and weakness

Peripheral Neuropathy, also known as Peripheral Nerve Damage, is a condition resulting from damage to the peripheral nerves, which are the nerves outside the brain and spinal cord. This damage can cause symptoms such as numbness, tingling, pain, and weakness, typically in the hands and feet. It can result from various causes, including diabetes, infections, traumatic injuries, and exposure to toxins.

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research Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States

50 citations , April 2021 in “Frontiers in Immunology”

This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.

research Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

46 citations , April 2021 in “International Journal of Molecular Sciences”

This review discusses the potential of curcumin and its formulations to mitigate neuropathic and postoperative pain, highlighting positive outcomes in preclinical and clinical studies but noting the need for further clinical research.

research Carences nutritionnelles liées à la chirurgie de l’obésité

54 citations , April 2007 in “Gastroentérologie clinique et biologique”

This review highlights that bariatric surgery can increase nutritional deficiencies in morbidly obese patients, with particular emphasis on the risks of deficiency due to reduced food intake and malabsorption.

Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

research Sexually dimorphic effect of progesterone and its reduced metabolites on the gene expression of myelin proteins in rat Schwann cells

May 2006 in “Frontiers in Neuroendocrinology”

This study found that patients with androgenic alopecia had altered neuroactive steroid levels and depression symptoms after stopping finasteride treatment, suggesting lingering neuropsychiatric effects.

research Hair follicle transplantation: implications for cell migration and wound healing

January 2016 in “Minerva Access (University of Melbourne)”

This dissertation found that hair follicle transplantation promoted wound healing in mice by enhancing wound re-epithelialization and increasing nerve density in the granulation tissue.

research Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells

11 citations , August 2023 in “Burns”

This review explores the molecular mechanisms through which NGF may enhance burn wound healing by reducing healing time and improving scar quality, but it presents no new clinical results.

research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain

50 citations , May 2019 in “Drugs”

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

research Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis

8 citations , June 2025 in “Stem Cell Research & Therapy”

This review discusses the potential of exosome therapy for treating diabetic peripheral neuropathy but highlights the need for more robust preclinical trials before clinical application.

research Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

28 citations , March 2017 in “Scientific Reports”

This study found that minoxidil may protect against chemotherapy-induced peripheral neuropathy and potentially support hair recovery and tumor suppression in mouse models.

research Episodic Neuropathic-Like Musculoskeletal Pain Associated With Ritlecitinib Therapy in Alopecia Universalis: A Case Report

1 citations , October 2025 in “Cureus”

In this case report, a 30-year-old male with alopecia universalis and autoimmune conditions experienced treatment failure with JAK inhibitors, including ritlecitinib, and developed severe musculoskeletal pain, indicating a potential novel adverse effect that warrants further pharmacovigilance.

research Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

1 citations , May 2021 in “Scientific Reports”

This study identified several anticancer drugs, including vinblastine and bortezomib, that significantly increase the risk of developing chemotherapy-induced peripheral neuropathy, with variations in time-to-onset among different drug categories.

research Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

22 citations , June 2018 in “Journal of Neuroinflammation”

This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.

research Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone

December 2023 in “Frontiers in pharmacology”

In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.

research Cutaneous manifestations of diabetic peripheral neuropathy

11 citations , January 2017 in “Dermato-endocrinology”

This study observed that common skin changes in patients with type 2 diabetes included peripheral hair loss, xerosis, anhydrosis, and nail alterations, underscoring the importance of controlling blood sugar and foot care to prevent neuropathy complications.

research Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

March 2024 in “Cancer Research”

This study found that eliminating senescent cells using senolytic drugs effectively prevented and reversed paclitaxel-induced peripheral neuropathy in mice.

research Lead, Mercury, and Arsenic Poisoning Due to Topical Use of Traditional Chinese Medicines

68 citations , May 2013 in “The American journal of medicine”

This report documents two cases of severe systemic poisoning from heavy metals after short-term use of traditional Chinese medicines for treating damaged or infected tissue.

research The Pathological Culprit of Neuropathic Skin Pain in Long COVID-19 Patients: A Case Series

5 citations , July 2022 in “Journal of Clinical Medicine”

This study found histopathological evidence of hypertrophy in nerve endings that may explain the cutaneous neurosensory symptoms in some long COVID-19 patients.

research A Case of Hemi‐Isaac's Syndrome

1 citations , August 2021 in “Movement disorders clinical practice”

This case report describes the first documented occurrence of hemi-Isaac's syndrome or acquired neuromyotonia affecting only one side of the body, with symptoms improving after immunomodulatory treatment.

research Novel ABCD1 Gene Mutation in Adrenomyeloneuropathy with Hypoplasia and Agenesis of the Corpus Callosum

7 citations , January 2018 in “Neurodegenerative Diseases”

This study identified a new clinical variant of adult adrenomyeloneuropathy characterized by hypoplasia and agenesis of the corpus callosum, associated with a novel ABCD1 gene mutation.

research Fluoroquinolone-induced serious, persistent, multisymptom adverse effects

39 citations , October 2015 in “Case Reports”

In this case series, four adults developed severe, disabling multisymptom illness potentially linked to fluoroquinolone use, which persisted and progressed even after discontinuation of the drug.

Weekly Docetaxel in Minimally Pretreated Cancer Patients: A Dose-Escalation Study Focused on Feasibility and Cumulative Toxicity of Long-Term Administration

research Weekly docetaxel in minimally pretreated cancer patients: A dose-escalation study focused on feasibility and cumulative toxicity of long-term administration

50 citations , June 1999 in “Annals of Oncology”

This study found that long-term weekly administration of docetaxel is feasible at doses up to 45 mg/m² per week with acceptable toxicity, and suggests further evaluation with 40 mg/m² for phase II studies.

research Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons

11 citations , September 2011 in “Biochemical journal”

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

research Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis

4 citations , April 2017 in “F1000Research”

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

research Neuropathic Pruritus: An Underrecognized and Often Misdiagnosed and Difficult to Treat Medical Condition

April 2023 in “IntechOpen eBooks”

This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.

research How Advancing is Peripheral Nerve Regeneration Using Nanofiber Scaffolds? A Comprehensive Review of the Literature

13 citations , November 2023 in “International Journal of Nanomedicine”

This review explores the potential of nanofiber scaffolds as an advanced intervention in peripheral nerve regeneration, detailing their fabrication, cellular interactions, controlled bioactive agent release, clinical translation prospects, emerging trends, and biocompatibility considerations for treating peripheral nerve injuries.

research Occipital Neuralgia after Hair Transplantation and Its Treatment

2 citations , January 2015 in “Case reports in neurological medicine”

In this case report, pulsed radiofrequency neuromodulation provided over 80% pain relief for five months in a patient with chronic lesser occipital nerve pain after other treatments failed.

research COVID-19-Related Neuropathic Pain: A Systematic Review and Meta-Analysis

18 citations , February 2023 in “Journal of Clinical Medicine”

This study reported that neuropathic pain is prevalent in 6.7% of hospitalized COVID-19 patients during the acute phase and 34.3% of long COVID patients, highlighting the need for additional research.

research Platinum-Induced Peripheral Neuropathy (PIPN): ROS-Related Mechanism, Therapeutic Agents, and Nanosystems

13 citations , November 2021 in “Frontiers in Molecular Biosciences”

This review discusses the mechanisms of platinum-induced peripheral neuropathy related to reactive oxygen species and explores potential antioxidant therapies and nanotechnology approaches, but reports no new clinical results.

research Chemotherapy-induced peripheral neuropathy: ice, compression, both, or neither?

13 citations , January 2020 in “Annals of Oncology”

Cryotherapy and compression therapy might help prevent chemotherapy nerve damage, but more research is needed.

research Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy

May 2026 in “International Journal of Molecular Sciences”

In this study, a new formulation of human placental extract showed antioxidant and neurite outgrowth activities, significantly reduced hair graying in mice, and alleviated neuropathy symptoms, suggesting potential therapeutic benefits.