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    Glossary Period Circadian Regulator 3

    gene influencing circadian rhythms and sleep patterns

    Period Circadian Regulator 3 (PER3) is a gene that plays a crucial role in regulating the body's internal clock, or circadian rhythm, which influences sleep-wake cycles and other daily physiological processes. Variations in the PER3 gene can affect sleep patterns and have been linked to sleep disorders and certain health conditions.

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    1. A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013 · 92 citations
    2. Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin International Journal of Molecular Sciences · 2016 · 63 citations
    3. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia Journal of Dermatological Science · 2012 · 59 citations
    4. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012 · 221 citations
    5. Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα Frontiers in Veterinary Science · 2023
    6. Hair Follicles as a Critical Model for Monitoring the Circadian Clock International Journal of Molecular Sciences · 2023 · 5 citations
    7. The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway Cells · 2024
    8. Congenital Adrenal Hyperplasia Journal of Pediatric and Adolescent Gynecology · 2011 · 100 citations
    9. Melatonin preparations in dermatological practice 2015
    10. Possible contribution of chronobiology to cardiovascular health Frontiers in physiology · 2014 · 29 citations
    11. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 116 citations
    12. Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells Journal of circadian rhythms · 2012 · 15 citations
    13. Disturbance of the Circadian System in Shift Work and Its Health Impact Journal of biological rhythms · 2021 · 103 citations
    14. The circadian molecular clock creates epidermal stem cell heterogeneity Nature · 2011 · 293 citations
    15. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations
    16. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022 · 32 citations
    17. The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth Archives of Dermatological Research · 2013 · 9 citations
    18. The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015 · 66 citations
    19. Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones Neuropsychopharmacology · 2019 · 197 citations
    20. The clock within Nature · 2011 · 6 citations
    21. Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing Frontiers in bioengineering and biotechnology · 2022 · 5 citations
    22. Circadian clocks: from stem cells to tissue homeostasis and regeneration EMBO Reports · 2017 · 84 citations
    23. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020 · 77 citations
    24. Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor BMC Endocrine Disorders · 2014 · 62 citations
    25. Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle Stem Cells · 2010 · 39 citations
    26. Functional analysis of the PIP5K1A gene in Liaoning Cashmere goats: an investigation based on bioinformatics, tissue localization, and biological functions Cellular and Molecular Biology · 2025
    27. Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions Journal of Investigative Dermatology · 2018 · 185 citations
    28. ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review) International Journal of Molecular Medicine · 2026
    29. Molecular insights into chronotype and time-of-day effects on decision-making Scientific reports · 2016 · 36 citations
    30. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor Springer eBooks · 2016