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    Glossary Patched 1

    Patched 1 (PTCH1) is a gene that encodes a protein involved in the Hedgehog signaling pathway, which plays a crucial role in regulating hair follicle development and cycling. Mutations or dysregulation of PTCH1 can lead to hair loss conditions, as it affects the proliferation and differentiation of hair follicle cells. Key distinguishing characteristics of PTCH1 include its involvement in both embryonic development and the maintenance of adult hair follicles, making it a significant factor in understanding hair biology and potential hair loss therapies.

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    Research 30 of 1000+

    1. Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression Cancer Research · 2006 · 176 citations
    2. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice Archives of Dermatological Research · 2001 · 14 citations
    3. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    4. Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1 SPIRE - Sciences Po Institutional REpository · 2024
    5. Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese 2022
    6. Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice bioRxiv (Cold Spring Harbor Laboratory) · 2018
    7. Application of microneedle patches for drug delivery; doorstep to novel therapies Journal of Tissue Engineering · 2022 · 76 citations
    8. Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride International Journal of Pharmaceutics · 2021 · 23 citations
    9. Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation Biomaterials Science · 2023 · 21 citations
    10. Fabrication of astaxanthin-loaded electrospun nanofiber-based mucoadhesive patches with water‐insoluble backing for the treatment of oral premalignant lesions Materials & design · 2022 · 13 citations
    11. The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis. PubMed · 2018 · 5 citations
    12. Nanocomposite patches for transdermal drug delivery: A review Science, Engineering and Health Studies · 2024 · 1 citations
    13. RETRACTED: Fabrication of Oro-Dispersible Sodium Valproate-Loaded Nanofibrous Patches for Immediate Epileptic Innervation ACS Biomaterials Science & Engineering · 2024 · 1 citations
    14. Fabrication and Characterization of 3BDO-Loaded Dissolvable Microneedle Patches for Hair Regrowth in C57BL/6 Mice Journal of Visualized Experiments · 2026
    15. Alopecic Patches on the Extremities of a Young Man JEADV Clinical Practice · 2026
    16. SILENT PATCHES, LOUD SCIENCE: REVISITING ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    17. SILENT PATCHES, LOUD SCIENCE: REVISITING ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    18. 18-20 year old with no bald patches or hair thinning but concerns regarding hair loss - tried ketoconazole with no effect, how to manage? Zenodo (CERN European Organization for Nuclear Research) · 2025
    19. Clinical Correlation Between Alopecia Areata and Salmon Patches: A Case Series AlQalam Journal of Medical and Applied Sciences · 2024
    20. Achieving Physiologic 17-ẞ-Estradiol Levels in Transgender Females on Estradiol Transdermal Patches and Optimal Dosing Journal of the Endocrine Society · 2021
    21. Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform International Journal of Pharmaceutics · 2024 · 7 citations
    22. Magnesium microneedle patches for under‐eye wrinkles Dermatologic Therapy · 2022 · 3 citations
    23. Development of topical patches releasing allicin using garlic extract Journal of Cosmetic Dermatology · 2021 · 3 citations
    24. Body temperature-responsive Janus patches accelerate diabetic wound regeneration via coupling mechanical transduction and biochemical pathways Journal of Controlled Release · 2026
    25. Persistent Alopecic Patches Following Dutasteride Mesotherapy for Female Androgenetic Alopecia: A Case Series Journal of Drugs in Dermatology · 2026
    26. Multiple Scaly Patches on the Scalp JEADV Clinical Practice · 2025
    27. Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration International Journal of Biological Macromolecules · 2025
    28. Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform bioRxiv (Cold Spring Harbor Laboratory) · 2023
    29. Poster abstract: Novel dissolving microarray patches for intradermal delivery of finasteride CRS 2020 Virtual Annual Meeting · 2020
    30. A Case Report of Alopecia Treated by Gagamsunbangpaedok-tang (Jiājiǎnxiānfángbàidú-tāng) - Focused on Multi-patched Alopecia Areata with Lymphadenopathy The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology · 2014 · 3 citations