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    Glossary Patched Receptor

    protein controlling cell growth via Hedgehog signaling pathway

    The Patched Receptor is a protein found on the surface of cells that plays a crucial role in regulating cell growth and development. It acts as a gatekeeper in the Hedgehog signaling pathway, which is important for embryonic development and tissue regeneration. When the Hedgehog protein binds to the Patched Receptor, it allows another protein called Smoothened to activate and send signals inside the cell, influencing gene expression. This pathway is also implicated in certain cancers when it malfunctions.

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    1. Emerging drugs for hypogonadism Expert Opinion on Emerging Drugs · 2006 · 10 citations
    2. Folliculotropic mycosis fungoides complicated by eosinophilia: a case report Chinese Journal of Dermatology · 2011
    3. 증례 : Gefitinib에 의해 유발된 반흔성 탈모증 대한피부과학회지 · 2013
    4. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice Archives of Dermatological Research · 2001 · 14 citations
    5. Glypican-1, -4 and 6 Participate in the Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7 and Patched 1 SPIRE - Sciences Po Institutional REpository · 2024
    6. sm“FISH”ing for Hedgehog 2016
    7. New Treatment Strategies in Management of Alopecia Areata: Review Article The Egyptian Journal of Hospital Medicine · 2023
    8. Erlotinib-related Severe Hair Loss with Severe Exanthematous Drug Eruption: A Case Report 대한피부과학회지 · 2018
    9. How the stress of fight or flight turns hair white Nature · 2020 · 7 citations
    10. Epidermal Renewal after Treatment of Primary Canine Hypothyroidism using Levothyroxine Acta Scientiae Veterinariae · 2021
    11. Cutaneous Side Effects of Chemotherapy and Radiotherapy 2016 · 2 citations
    12. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    13. Managing the adverse effects of cytotoxic chemotherapy at the level of primary healthcare 2023 · 1 citations
    14. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    15. Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese 2022
    16. Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators Acta crystallographica · 2008 · 1 citations
    17. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    18. Touch Receptors Undergo Rapid Remodeling in Healthy Skin Cell Reports · 2016 · 31 citations
    19. Melatonin membrane receptors in peripheral tissues: Distribution and functions Molecular and Cellular Endocrinology · 2012 · 506 citations
    20. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators Climacteric · 2007 · 67 citations
    21. Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation Biomaterials Science · 2023 · 21 citations
    22. Hepatotoxicity Associated with Anabolic Androgenic Steroids and Selective Androgen Receptor Modulators: A Literature Review Medical Science · 2025
    23. Hair Loss in Patients on Glucagon-Like Peptide 1 Receptor Agonists: Understanding Risks and Managing Outcomes Dermatology and Therapy · 2026
    24. Poster abstract: Novel dissolving microarray patches for intradermal delivery of finasteride CRS 2020 Virtual Annual Meeting · 2020
    25. Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells Gastroenterology · 2010 · 291 citations
    26. Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment Frontiers in Natural Products · 2026
    27. Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression Cancer Research · 2006 · 176 citations
    28. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    29. Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects Journal of dermatological treatment · 2019 · 8 citations
    30. The role of vitamin D receptor mutations in the development of alopecia Molecular and Cellular Endocrinology · 2011 · 109 citations