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    Glossary Parathyroid Hormone-CBD

    modified parathyroid hormone targets collagen in bone for treatment

    Parathyroid Hormone-CBD (PTH-CBD) is a modified form of parathyroid hormone that includes a collagen binding domain. This modification allows the hormone to specifically target and bind to collagen in the bone matrix, potentially enhancing its effectiveness in treating conditions like osteoporosis by promoting bone growth and repair more efficiently.

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    Research 30 of 476

    1. A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone–Collagen Binding Domain (PTH–CBD), Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female Mice Calcified Tissue International · 2012 · 23 citations
    2. Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model Anti-Cancer Drugs · 2013 · 20 citations
    3. Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain Journal of Investigative Dermatology Symposium Proceedings · 2015 · 12 citations
    4. Parathyroid hormone linked to a collagen binding domain promotes hair growth in a mouse model of chemotherapy-induced alopecia in a dose-dependent manner Anti-Cancer Drugs · 2014 · 8 citations
    5. Treatment of Alopecia Areata in Mice by Stimulating the Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain Journal of clinical & experimental dermatology research · 2015
    6. Treatment for chemotherapy‐induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain International Journal of Cancer · 2011 · 24 citations
    7. ISID1108 - Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata. 2023
    8. The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia Skin Pharmacology and Physiology · 2015 · 15 citations
    9. Hair & Cutaneous Development Journal of Investigative Dermatology · 2012
    10. 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata 2023
    11. Chemotherapy‐induced alopecia – the urgent need for treatment options 2018 · 4 citations
    12. Present Chemotherapy Induced Alopecia and Research in Future Austin therapeutics · 2021
    13. Emerging treatments in alopecia Expert Opinion on Emerging Drugs · 2014 · 47 citations
    14. New drugs under investigation for the treatment of alopecias Expert Opinion on Investigational Drugs · 2019 · 26 citations
    15. Structures of three polycystic kidney disease-like domains from<i>Clostridium histolyticum</i>collagenases ColG and ColH Acta Crystallographica Section D: Structural Biology · 2015 · 18 citations
    16. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice Environmental Toxicology and Pharmacology · 2016 · 14 citations
    17. Scalp hypothermia for the prevention of chemotherapy-induced alopecia in breast cancer Journal of Modern Oncology · 2024 · 1 citations
    18. A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily, High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata. PubMed · 2025
    19. Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail—Implications for Disease and Regeneration International Journal of Molecular Sciences · 2026
    20. Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia Investigational new drugs · 2019 · 5 citations
    21. Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease Cell Transplantation · 2016 · 1 citations
    22. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings of the National Academy of Sciences · 1994 · 211 citations
    23. Parathyroid Hormone-related Protein in Normal and Neoplastic Canine Tissues: Immunohistochemical Localization and Biochemical Extraction Veterinary Pathology · 1994 · 54 citations
    24. Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition 2003 · 52 citations
    25. Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin Journal of Investigative Dermatology · 2006 · 33 citations
    26. A Topical Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Antagonist Stimulates Hair Growth in Mice Endocrinology · 2006 · 26 citations
    27. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation Journal of Investigative Dermatology · 2016 · 24 citations
    28. Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D3 and parathyroid hormone-related peptide in dermatology: a new perspective. PubMed · 1996 · 23 citations
    29. Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth? Experimental Dermatology · 2014 · 9 citations
    30. The parathyroid hormone-related protein as a regulator of normal tissue functions Current Opinion in Endocrinology & Diabetes · 1994 · 4 citations