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    Glossary p53

    regulates cell division and prevents tumor formation

    p53, also known as TP53 or Tumor Protein p53, is a crucial gene that produces a protein responsible for regulating cell division and preventing tumor formation. Often referred to as the "guardian of the genome," p53 helps repair damaged DNA or triggers cell death if the damage is irreparable, thereby playing a vital role in cancer prevention.

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    1. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis Carcinogenesis · 2003 · 138 citations
    2. p53 Involvement in the Control of Murine Hair Follicle Regression American Journal of Pathology · 2001 · 71 citations
    3. The Paradox of p53: What, How, and Why? Cold Spring Harbor Perspectives in Medicine · 2016 · 64 citations
    4. c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013 · 60 citations
    5. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    6. p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss FEBS Letters · 2010 · 37 citations
    7. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    8. Epimorphic regeneration in mice is p53-independent Cell Cycle · 2010 · 20 citations
    9. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015 · 19 citations
    10. Identical p53 gene mutation in malignant proliferating trichilemmal tumour of the scalp and small cell carcinoma of the common bile duct: the necessity for therapeutic caution? 2008 · 11 citations
    11. Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway Regenerative Therapy · 2024 · 8 citations
    12. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    13. Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53 BMC Complementary and Alternative Medicine · 2019 · 2 citations
    14. Skin epidermal keratinocyte p53 induces food uptake upon UV exposure Frontiers in Behavioral Neuroscience · 2023 · 1 citations
    15. Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris Archives of Dermatological Research · 2022 · 1 citations
    16. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations
    17. Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade Jundishapur Journal of Natural Pharmaceutical Products · 2021 · 1 citations
    18. P53 Acute west nile virus infection in an SLE patient – diagnostic and therapeutic challenges Poster presentations · 2020 · 1 citations
    19. Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1 ‐mediated P53 ubiquitination Animal Models and Experimental Medicine · 2026
    20. VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway Animals · 2025
    21. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    22. Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris Research Square (Research Square) · 2022
    23. Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris Research Square (Research Square) · 2022
    24. Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation 2012
    25. Differential Regulation of Vitamin D Receptor (VDR) By P53, P63 and P73 OhioLink ETD Center (Ohio Library and Information Network) · 2009
    26. Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression Chemico-Biological Interactions · 2024
    27. Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice Food frontiers · 2023
    28. 5-Bromo-2′-deoxyuridine induced effluvium via p53-mediated CD326-positive keratinocyte apoptosis in C57BL/6 mice Journal of Dermatology · 2016
    29. S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma American Journal Of Pathology · 2020 · 32 citations
    30. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019 · 13 citations