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    Glossary Non-canonical Wnt Pathway

    regulates cell movement and organization without using β-catenin

    The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

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    1. Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway Oncotarget · 2017 · 11 citations
    2. Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles Journal of Molecular Histology · 2016 · 5 citations
    3. Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes Cancer Research · 2010
    4. Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos PLoS ONE · 2018 · 23 citations
    5. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    6. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    7. Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair International Journal of Molecular Sciences · 2022 · 11 citations
    8. Wound healing in development Birth Defects Research · 2012 · 29 citations
    9. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice International Journal of Molecular Medicine · 2018 · 23 citations
    10. Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems The International Journal of Developmental Biology · 2023 · 21 citations
    11. Extrinsic control of Wnt signaling in the intestine Differentiation · 2017 · 87 citations
    12. Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts Frontiers in Cell and Developmental Biology · 2021 · 24 citations
    13. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway International Journal of Biological Sciences · 2023 · 9 citations
    14. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    15. Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics Journal of Investigative Dermatology · 2014 · 16 citations
    16. Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells Journal of Dermatological Science · 2007 · 14 citations
    17. The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration Biomolecules · 2023 · 2 citations
    18. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    19. Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation Journal of Investigative Dermatology · 2016 · 8 citations
    20. Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation Journal of Investigative Dermatology · 2026
    21. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells Biochemical and Biophysical Research Communications · 2006 · 28 citations
    22. Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin Frontiers in physiology · 2018 · 37 citations
    23. Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells Scientific Reports · 2021 · 24 citations
    24. LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway Molecular Medicine Reports · 2017 · 25 citations
    25. Transcriptome Sequencing and Mass Spectrometry Reveal Genes Involved in the Non-mendelian Inheritance-Mediated Feather Growth Rate in Chicken Biochemical genetics · 2024
    26. Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells Burns & Trauma · 2022 · 1 citations
    27. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators Nature Cell Biology · 2014 · 173 citations
    28. Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice International journal of medical sciences · 2013 · 19 citations
    29. Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment The Journal of Cell Biology · 2025 · 4 citations
    30. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations