March 2024 in “International journal of pharmaceutics. X” This study explored the use of spanlastic vesicles to enhance the delivery of bimatoprost for treating alopecia and found that a bimatoprost-loaded nanogel significantly increased skin drug accumulation and improved hair regrowth in a mouse model, outperforming both naive bimatoprost gel and commercial minoxidil formulations.
1 citations
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January 2017 in “PubMed” This study found that despite chemical differences, five different brands of reconstructive hair fibers all provided successful cosmetic results in disguising hair loss in patients.
2 citations
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January 2023 in “BioMed Research International” The researchers reported that a 5% Beta vulgaris L. extract nanogel showed better antialopecic activity in testosterone-induced alopecia in mice compared to a 2.5% concentration.
December 2023 in “International Journal of Dermatology” This study reports that trichoscopy and histopathology can effectively diagnose alopecia areata incognito and differentiate it from telogen effluvium or androgenetic alopecia, aiding clinicians in better hair regrowth management.
February 2023 in “Siriraj Medical Journal” This study found that acute alopecia areata features more terminal telogens and vellus hairs, while chronic alopecia areata shows more follicular streamers and nanogen hairs.
This study reported that combining vertical and horizontal sectioning in scalp biopsies allows for a more thorough examination of histological changes in various types of alopecia.
1 citations
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December 2023 in “Egyptian Journal of Veterinary Science” In this study, researchers found that a nanoparticle gel derived from Astragalus polysaccharides improved wound healing significantly more than a Gold-Silver nanocomposite gel and untreated controls, with better wound closure observed by the 15th day.
30 citations
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December 2017 in “Advanced Healthcare Materials” This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.
29 citations
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April 2017 in “Macromolecular bioscience” In this study, researchers developed a pH-sensitive dendritic polyglycerol nanogel to measure pH inside hair follicles using an ex vivo porcine ear model, finding that the pH increases from 6.5 at the skin surface to 7.4 in deeper follicle areas, without observed toxicity.
This study introduced fibronectin nanogel microneedles (FNG MNs) that demonstrated improved tissue penetration and transdermal delivery, restoring skin homeostasis in a photoaged mouse model and enhancing collagen deposition and angiogenesis in a diabetic wound rat model.
62 citations
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November 2016 in “Nanoscale” In this study, researchers developed thermoresponsive nanogels that effectively penetrate hair follicles and release a model drug when triggered by temperature, demonstrating greater penetration for medium to large nanogels (300–500 nm) compared to smaller ones.
June 2026 in “ACS Nano Medicine” The study presents the development of fibronectin nanogel microneedles (FNG MNs) designed to enhance tissue penetration and transdermal delivery for anti-aging and diabetic wound healing applications. The FNG MNs, with an average size of 82.0 nm, demonstrate excellent stability, cytocompatibility, and cell penetration capabilities. In a photoaged mouse model, these microneedles effectively restore skin homeostasis by normalizing epidermal thickness, reorganizing collagen and elastin fibers, and reducing inflammation and oxidative stress. In a diabetic wound rat model, FNG MNs promote collagen deposition, hair follicle neogenesis, and angiogenesis while reducing Yes-associated protein expression. These findings suggest that FNG MNs could be a promising formulation for various biomedical applications due to their ability to modulate the extracellular matrix, reduce inflammation, and provide antioxidative benefits.
December 2023 in “̒Ulūm-i dārūyī” This review provides a comprehensive examination of the causes and treatments for hirsutism in women, highlighting the role of pharmacological therapies and novel nanotechnology-based methods in improving patient quality of life.
7 citations
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June 2025 in “Nano Energy” This study reports that triboelectro-responsive DNA hydrogels, enhanced with conductive polymers and triboelectric stimulation, effectively accelerate wound healing and exhibit strong anti-bacterial and anti-inflammatory properties, achieving 99.8% closure of bacterium-infected diabetic wounds in 14 days.
1 citations
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July 2008 in “Expert Review of Dermatology” Normal hair thickness varies by scalp area and a mix of hair thicknesses is typical in healthy individuals.
October 2024 in “International Journal of Pharma Professional’s Research (IJPPR)” This study developed and characterized Quercetin-loaded nanogels, finding that they showed promising potential for enhanced drug delivery and stability in treating Alopecia, with an optimized batch achieving a drug release of 95.32% over 12 hours.
64 citations
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July 1997 in “Journal of The American Academy of Dermatology” This study found that eosinophils are a useful diagnostic feature for alopecia areata, especially when the typical "swarm of bees" lymphoid infiltrate is absent, helping differentiate it from trichotillomania.
19 citations
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February 2016 in “Journal of The American Academy of Dermatology” This study found that the presence of CD3(+) T-cells within empty follicular fibrous tracts is a reliable indicator for diagnosing diffuse alopecia areata instead of pattern hair loss.
17 citations
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September 2012 in “Dermatologic Clinics” This review discusses histologic findings in alopecia and emphasizes the importance of understanding normal follicular anatomy and cycles in transverse sections, without reporting new results.
58 citations
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September 2012 in “Dermatologic Clinics” This article reviews current knowledge on the causes, diagnosis, and medical treatments for androgenetic alopecia, particularly in men, and reports no new findings.
54 citations
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August 2009 in “Dermatologic Surgery” This review outlines the steps of contemporary hair transplantation surgery, including the roles of medications and nonsurgical options, but it reports no new clinical findings.
20 citations
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October 2013 in “British Journal of Dermatology” The document concludes that clinicians should be aware of common hair and scalp disorders in women of African descent and that more research is needed to develop effective treatments.
1 citations
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July 2018 in “Elsevier eBooks” This review discusses the basic principles of hair pathology and findings in common types of alopecia but reports no new research results.
July 2018 in “Elsevier eBooks” This chapter details the causes and diagnostic process of pediatric alopecia, including trichoscopic findings, but reports no new clinical results.
42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.
27 citations
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September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review discusses recent advances in hair regeneration therapies, highlighting the potential of nanotechnology and pluripotent stem cells, and reports no new results, emphasizing the need for further research.
6 citations
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December 2013 in “Journal of Cosmetic Dermatology” This article reviews the use of pigmented concealing powders as a viable cosmetic option for patients with alopecia, noting the potential for a more natural appearance compared to traditional hairstyling or hairpieces, but it presents no new clinical results.
5 citations
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March 2001 in “Journal of biomechanics” This study found that anagen hairs require less force to be extracted than telogen hairs in an in vitro pig skin model, indicating different anchorage mechanisms.
This chapter reviews the prevalence, pathogenesis, and management of hair and scalp disorders but reports no new clinical findings.
March 2026 in “Frontiers in Medicine” This study provides a framework for understanding different types of alopecias based on immune privilege collapse at specific follicular sites, revealing distinct patterns in immune effector programs and stromal influences depending on the alopecia type.