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    Glossary mTORC1

    protein complex regulating cell growth and metabolism

    mTORC1, or mechanistic Target of Rapamycin Complex 1, is a protein complex that plays a crucial role in regulating cell growth, protein synthesis, and metabolism in response to nutrients and growth factors. It acts as a central hub for integrating signals from the environment to control cellular processes, making it essential for normal cell function and growth.

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    1. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin Experimental Dermatology · 2015 · 74 citations
    2. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    3. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    4. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    5. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    6. Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress Cell death and disease · 2017 · 21 citations
    7. Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers Brain Research Bulletin · 2018 · 14 citations
    8. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    9. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    10. The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Scientific reports · 2019 · 9 citations
    11. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    12. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    13. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    14. Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling Journal of Dermatological Science · 2026
    15. Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia. PubMed · 2025
    16. Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model Journal of Photochemistry and Photobiology B Biology · 2025
    17. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    18. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    19. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
    20. 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity Journal of Investigative Dermatology · 2022
    21. 650 Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation 2022
    22. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    23. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    24. Folliculin encoded by the <i>BHD</i> gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Proceedings of the National Academy of Sciences · 2006 · 475 citations
    25. Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia Acta histochemica · 2018 · 5 citations
    26. 0843 N6-methyladenosine RNA modification promotes keratinocyte proliferation and cutaneous wound repair through regulation of MTOR stability Journal of Investigative Dermatology · 2025 · 1 citations
    27. 176 Myeloid cell-specific deletion of mTOR suppresses psoriasis-like skin inflammation in C57BL/6 mice Journal of Investigative Dermatology · 2023
    28. 1341 Possible role of mTOR signaling pathway in radiation dermatitis Journal of Investigative Dermatology · 2023
    29. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway Discovery medicine · 2023
    30. Elevated Mammalian Target of Rapamycin (mTOR) Gene Expression in Acne Vulgaris patients 2023