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    Glossary Morphogen

    signaling molecule guiding tissue development based on concentration gradient

    A morphogen is a type of signaling molecule that governs the pattern of tissue development in the process of morphogenesis, and it helps cells determine their fate based on its concentration gradient. Essentially, morphogens provide positional information to cells, guiding them to form specific structures or tissues during embryonic development.

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    1. Self‐organizing hair peg‐like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field Experimental Dermatology · 2019 · 26 citations
    2. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    3. 1435 Dynamic morphogen-p63 chromatin interactions that guide epigenetic changes and p63 activity in surface ectoderm commitment Journal of Investigative Dermatology · 2018
    4. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001 · 949 citations
    5. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    6. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Development · 2013 · 60 citations
    7. Molecular histology in skin appendage morphogenesis Microscopy Research and Technique · 1997 · 57 citations
    8. Morphogenesis of the hair follicle during catagen Cell and Tissue Research · 1970 · 56 citations
    9. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells Experimental Dermatology · 2012 · 46 citations
    10. Morphogenesis of the antenna of the male silkmoth. Antheraea polyphemus, III. Development of olfactory sensilla and the properties of hair-forming cells Tissue and Cell · 1991 · 46 citations
    11. Adhesion Molecules in Skin Development: Morphogenesis of Feather and Hair<sup>a</sup> Annals of the New York Academy of Sciences · 1991 · 45 citations
    12. Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne Nature Communications · 2018 · 43 citations
    13. Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State Stem Cells · 2013 · 31 citations
    14. Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022 · 21 citations
    15. Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium Journal of molecular medicine · 2010 · 21 citations
    16. Morphogenesis of the Hair Follicle during the Ontogeny of Human Skin 1988 · 14 citations
    17. An In Vitro Model for the Morphogenesis of Hair Follicle Dermal Papillae Journal of Investigative Dermatology · 2013 · 10 citations
    18. Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells BioMed research international · 2013 · 7 citations
    19. [Genetic expression and morphogenesis of the skin in vertebrates]. PubMed · 1993 · 5 citations
    20. Organ Culture of Developing Mouse Skin and Its Application for Molecular Mechanistic Studies of Morphogenesis Humana Press eBooks · 2004 · 4 citations
    21. Morphogenesis of Mammary Glands in Buffalo (<i>Bubalus bubalis</i>) Anatomy Research International · 2014 · 3 citations
    22. Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep International journal of molecular sciences · 2024 · 1 citations
    23. A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    24. Methods for Treating Androgenic Alopecia by Restoration of Morphogenetic Field Connectivity in Hair Follicle Networks Zenodo (CERN European Organization for Nuclear Research) · 2026
    25. Methods for Treating Disorders of Tissue Function by Restoration of Morphogenetic Field Connectivity: General Prior Art Disclosure Zenodo (CERN European Organization for Nuclear Research) · 2026
    26. Methods for Treating Disorders of Tissue Function by Restoration of Morphogenetic Field Connectivity: General Prior Art Disclosure Zenodo (CERN European Organization for Nuclear Research) · 2026
    27. Methods for Treating Androgenic Alopecia by Restoration of Morphogenetic Field Connectivity in Hair Follicle Networks Zenodo (CERN European Organization for Nuclear Research) · 2026
    28. 439 Gradients of Mesenchymal Stiffness Control Sweat Gland Cell Fate Specification During Morphogenesis Journal of Investigative Dermatology · 2025
    29. Morphogenetic Events in Hair Follicle Heterotypic Spheroids 2017
    30. 251 Morphogenetic events in hair follicle heterotypic spheroids Journal of Investigative Dermatology · 2017