31 citations
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February 2014 in “Inflammation Research” This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.
24 citations
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January 2012 in “Journal of Cellular Biochemistry” This study found that C-reactive protein may enhance monocyte adhesion to endothelial cells through NOX-mediated oxidative stress, suggesting a potential mechanism for atherogenesis.
6 citations
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April 2025 in “Communications Biology” In this study, researchers used a murine model of irritant contact dermatitis to reveal that hair follicle regions serve as key sites for neutrophil transepidermal migration, which requires MMP-9 expression stimulated by dermal monocytes.
6 citations
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October 2017 in “Oncotarget” In this study, NIH hairless mice showed increased susceptibility to Listeria monocytogenes infection compared to NIH mice, potentially due to differences in gut microbiota and monocyte levels.
4 citations
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February 2022 in “Journal of Cosmetic Dermatology” This study found that patients with telogen effluvium had a higher rate of acute hair loss and lower monocyte counts if they had contracted COVID-19 prior to hair loss onset.
3 citations
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October 2024 in “Experimental Dermatology” This study found that patients with alopecia areata exhibited increased CRHR1 expression on circulating monocytes compared to controls, suggesting that stress-related factors like CRH and CRHR1 may contribute to the development and progression of the condition, particularly in chronic cases and those with larger lesions.
2 citations
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February 2023 in “BMC women's health” In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.
1 citations
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January 1985 in “Protides of the biological fluids” This study found that injecting highly purified monocyto-angiotropin into hare skin induced new blood vessel formation and significantly accelerated hair growth at the injection site compared to control areas.
September 2025 in “e-space (Manchester Metropolitan University)” This study found that testosterone and its metabolite DHT reduced macrophage-mediated phagocytosis of bacteria like MRSA and P. aeruginosa in vitro, and blocking testosterone's conversion to DHT improved bacterial clearance, suggesting potential therapeutic strategies for combating wound infections in the elderly.
July 2025 in “Journal of Investigative Dermatology” Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.
October 2023 in “Dermatology practical & conceptual” In this study, AMD was observed more frequently in AGA patients, and a higher monocyte/HDL ratio was associated with increased AMD severity, especially in men.
January 2023 in “Mansoura Medical Journal” This study suggests that increased levels of ischemia-modified albumin, indicating oxidative stress, are associated with greater severity of acne vulgaris.
September 2024 in “Dokumentenrepositorium der RUB (Ruhr University Bochum)” This study found that patients with higher baseline monocyte counts (\(\geq\) 925/\(\mu\)l) were significantly more likely to see treatment failure with adalimumab for hidradenitis suppurativa.
April 2016 in “Journal of Investigative Dermatology” This study found that the CD301b-expressing subpopulation of macrophages plays a crucial role in promoting reparative processes during the mid-stage of skin wound healing in a mouse model.
101 citations
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July 1998 in “Journal of Investigative Dermatology” This study found that UV exposure in human skin induces IL-10 production by macrophages, while Langerhans cells are depleted and their IL-12 production is downregulated.
2 citations
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September 2024 in “Journal of the American Academy of Dermatology” Higher monocyte counts may predict poor response to adalimumab in hidradenitis suppurativa patients.
This study found that adding calcitriol to metformin significantly improved symptoms in patients with polycystic ovary syndrome and decreased serum MCP-1 levels compared to metformin alone.
November 2023 in “Journal of Investigative Dermatology” Highly active but fewer CD14+CD16- monocytes are found in Alopecia Areata patients, regardless of severity.
August 2026 in “Bone and Joint Research” In this study, tibial cortex transverse transport accelerated wound healing in diabetic rats, potentially through enhanced mobilization of non-classical monocytes and increased M2 macrophage polarization.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers used a computational drug repurposing approach to identify FDA-approved drugs Dutasteride and Solifenacin as potential inhibitors of Listeria monocytogenes via binding to the virulence factor regulator PrfA, suggesting they may offer new treatment strategies against multi-drug resistant strains.
This study utilized a mouse model of traumatic brain injury to reveal that acute neurotrauma triggers widespread lipid metabolism reprogramming and storage lipid accumulation in microglial and monocyte populations, leading to lysosomal dysfunction, inhibited autophagy, and exacerbated inflammation through a pathological feedback loop.
January 2019 in “ISGE series” This study found that estradiol and other sex steroids reduced the capture of monocytes by human endothelial cells in vitro, potentially inhibiting the formation of atherosclerosis by promoting nCAM polysialylation, which interferes with leukocyte tethering to the vascular endothelium.
September 2025 in “Deleted Journal” This study found that in vitro environments simulating testosterone levels in elderly males, testosterone and its metabolite DHT significantly reduced macrophages' ability to phagocytize MRSA and Pseudomonas aeruginosa, suggesting AR manipulation and inhibiting testosterone-DHT conversion might help fight wound infections in the elderly.
610 citations
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April 2014 in “Nature Reviews Immunology” This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.
286 citations
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June 2012 in “Nature Immunology” In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.
130 citations
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September 2018 in “Cell Reports” This study found that macrophages play a crucial role in nerve regeneration by regulating Schwann cell dynamics and remyelination, with Gas6 identified as a key factor in this process.
116 citations
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October 1982 in “The Journal of Pathology” This study found that high-dose Cyclosporin A in rats led to significant functional and structural changes, including liver, kidney, and immune system alterations, along with behavioral and hematological effects.
56 citations
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November 2012 in “Endocrinology” This study found that the absence of vitamin D receptor signaling in mice impairs the inflammatory response to skin injury, particularly affecting macrophage recruitment and granulation tissue formation.
55 citations
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June 2012 in “Steroids” This study found that testosterone modulates vascular cell behavior through direct actions that do not rely on its conversion to estradiol.
53 citations
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April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.