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    Glossary Metabolic Activity

    Metabolic activity refers to the biochemical processes that occur within living organisms to maintain life, including the conversion of nutrients into energy and the synthesis of essential molecules. In the context of hair loss, metabolic activity is crucial as it influences hair follicle health, growth cycles, and overall hair density. Key distinguishing characteristics include the role of hormones, nutrients, and cellular signaling pathways that can either promote or inhibit hair growth, making metabolic activity a significant factor in conditions like androgenetic alopecia and telogen effluvium. Understanding metabolic activity can help in developing targeted treatments for hair loss by addressing underlying metabolic imbalances.

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    1. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    2. 558 The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2022
    3. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue Journal of visualized experiments · 2018 · 10 citations
    4. From PCOS to PMOS: The Impact of Physical Activity, Diet, and Metabolic Health on the Course of Polyendocrine Metabolic Ovarian Syndrome Quality in Sport · 2026
    5. Red LED Photobiomodulation Enhances Metabolic Activity in Cultured Human Pericytes Journal of Hard Tissue Biology · 2026
    6. The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff Journal of Investigative Dermatology Symposium Proceedings · 2005 · 241 citations
    7. Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity Stem cells · 2018 · 24 citations
    8. Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate The journal of experimental zoology · 1949 · 25 citations
    9. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    10. A Pro-Regenerative Petroleum Jelly-Based, Copper-Doped Bioactive Glass Ointment for Impaired Wound Healing in Metabolic Syndrome bioRxiv (Cold Spring Harbor Laboratory) · 2026
    11. Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways Cell Proliferation · 2025
    12. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin Nature communications · 2019 · 36 citations
    13. Antiandrogenic activities of<i>Glycyrrhiza glabra</i>in male rats International Journal of Andrology · 2009 · 15 citations
    14. Anti-Müllerian Hormone and Ovarian Morphology in Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS): Toward More Precise Diagnosis and Phenotype Stratification Biomedical and Therapeutics Letters · 2026
    15. Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review) Biomedical reports · 2024
    16. NEONATAL INHIBITION OF ANDROGEN ACTIVITY ALTERS THE PROGRAMMING OF BODY WEIGHT AND OREXINERGIC PEPTIDES DIFFERENTIALLY IN MALE AND FEMALE RATS Brain research bulletin · 2024
    17. Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo Journal of Investigative Dermatology · 1987 · 66 citations
    18. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998 · 45 citations
    19. Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models Skin Pharmacology and Physiology · 2002 · 42 citations
    20. Rapid high-performance liquid chromatogaphic method for detection of interindividual differences in carcinogen metabolism Journal of Chromatography B Biomedical Sciences and Applications · 1983 · 9 citations
    21. Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of <i>WNT</i>/signaling, mitochondrial activity, and stem cells maintenance Journal of Cosmetic Dermatology · 2020 · 8 citations
    22. ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA Dermatologic Clinics · 1999 · 4 citations
    23. Lactate dehydrogenase activity drives hair follicle stem cell activation Nature cell biology · 2017 · 202 citations
    24. Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors? Journal of Reproductive Immunology · 2016 · 26 citations
    25. Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity 2020 · 3 citations
    26. Anti-Androgenicity of Flutamide and its Metabolite Sch 16423 Biochemical Society Transactions · 1979 · 72 citations
    27. Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis British Journal of Dermatology · 1997 · 12 citations
    28. Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators International Journal of Cosmetic Science · 2000 · 3 citations
    29. 1032 Characterization of the human scalp hair follicle microbiome reveals differential spatial distribution, abundance and viability of intrafollicular microbiota and modulation of hair growth and metabolism by staphylococcus epidermidis Journal of Investigative Dermatology · 2023
    30. 865 Single-cell protein activity inference analysis of full-thickness skin uncovers novel pathways and a rare Arg1+ macrophage population in AA Journal of Investigative Dermatology · 2022