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    Glossary Melanin

    natural pigment determining skin, hair, and eye color

    Melanin is a natural pigment found in most organisms, responsible for the color of skin, hair, and eyes. It is produced by cells called melanocytes and provides protection against ultraviolet (UV) radiation by absorbing and dissipating sunlight.

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    1. Melanin Pigmentary Disorders: Treatment Update Dermatologic Clinics · 2005 · 84 citations
    2. STIMULATING EFFECT OF ADRENALECTOMY ON HAIR GROWTH AND MELANIN DEPOSITION IN BLACK RATS FED DIETS ADEQUATE AND DEFICIENT IN THE FILTRATE FACTORS OF VITAMIN B<sup>1</sup> Endocrinology · 1943 · 34 citations
    3. THE EFFECTS OF THE SYNTHETIC AND NATURAL HORMONE OF THE ADRENAL CORTEX ON MELANIN DEPOSITION IN ADRENALECTOMIZED BLACK RATS FED DIETS ADEQUATE AND DEFICIENT IN THE FILTRATE FACTORS OF VITAMIN B<sup>1</sup> Endocrinology · 1945 · 27 citations
    4. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    5. Microneedling dilates the follicular infundibulum and increases transfollicular absorption of liposomal sepia melanin Clinical, Cosmetic and Investigational Dermatology · 2015 · 25 citations
    6. When the Circadian Clock Meets the Melanin Pigmentary System Journal of Investigative Dermatology · 2015 · 18 citations
    7. Sex Identification of Feather Color in Geese and the Expression of Melanin in Embryonic Dorsal Skin Feather Follicles Animals · 2022 · 14 citations
    8. Circulating testosterone and feather-gene expression of receptors and metabolic enzymes in relation to melanin-based colouration in the barn owl General and comparative endocrinology · 2017 · 14 citations
    9. Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway Molecules · 2020 · 12 citations
    10. Extradermal melanin transfer? Lack of macroscopic spleen melanization in old C57BL/6 mice with de-synchronized hair cycle. Acta Biochimica Polonica · 2009 · 10 citations
    11. Effects of Aging on Hair Color, Melanosomes, and Melanin Composition in Japanese Males and Their Sex Differences International Journal of Molecular Sciences · 2022 · 7 citations
    12. Photo‐protective effect of cuttlefish ink melanin on human hair Journal of Applied Polymer Science · 2021 · 7 citations
    13. Field melanin mapping of the hairless scalp Skin Research and Technology · 2011 · 7 citations
    14. Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer Frontiers in pharmacology · 2022 · 6 citations
    15. Melanin Light Absorption as the Necessary but Not Sufficient Condition for Photoepilation: Miniaturization and Eclipse Phenomena The American Journal of Cosmetic Surgery · 2013 · 4 citations
    16. Raman investigation of in vivo radiation exposure on melanin in murine hair PNAS Nexus · 2025 · 2 citations
    17. Dynamic Transcriptome Profile Analysis of Mechanisms Related to Melanin Deposition in Chicken Muscle Development Animals · 2024 · 2 citations
    18. Biocompatible exosomes derived from <i>Pinctada martensii</i> mucus for therapeutic melanin regulation via α-MSH/NF-κB/MITF pathway Regenerative Biomaterials · 2025 · 1 citations
    19. Desmodesmus pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing Life · 2024 · 1 citations
    20. Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition Plants · 2023 · 1 citations
    21. Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 1 citations
    22. Mitigation of epidermal growth factor receptor inhibitor-induced side effects utilizing melanin and vascular-specific lasers: A case report series Journal of cosmetic and laser therapy · 2017 · 1 citations
    23. Marine-Biomass-Derived Melanin–Chitosan Composites as Natural Black Hair Colorants: Charge Reversal and Electrostatic Deposition Mechanism Organics · 2026
    24. The Development of Squid Ink Melanin Nanoparticles as a Multifunctional Colorant Anchored on Hair Fibers: Preparation, Physicochemical Characterization and Dyeing Performance Biomolecules · 2026
    25. Effect of mesenchymal stem cells on reducing melanin levels in response to UV radiation in male C57BL/6 mice Journal of Advanced Biotechnology and Experimental Therapeutics · 2025
    26. In Vivo Non-Invasive Observation of Dynamic Changes in Hair Shaft, Melanin, and Collagen During the C57BL/6 Follicle Cycle bioRxiv (Cold Spring Harbor Laboratory) · 2025
    27. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    28. Herbal insights into melanin synthesis: Enhancing hair health naturally International Journal of Herbal Medicine · 2024
    29. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    30. Increased PHGDH expression promotes aberrant melanin accumulation DSpace@MIT (Massachusetts Institute of Technology) · 2019