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    Glossary Mast Cell

    Mast cells are a type of white blood cell that play a crucial role in the immune system, particularly in allergic reactions and inflammation. In the context of hair loss, mast cells are relevant due to their involvement in the inflammatory processes that can affect hair follicles, potentially leading to conditions such as alopecia areata. Key distinguishing characteristics of mast cells include their large granules filled with histamine and other mediators, which can influence blood flow and immune responses in the skin and hair follicles. Their activation and degranulation can contribute to the disruption of normal hair growth cycles.

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    1. Endocannabinoids limit excessive mast cell maturation and activation in human skin Journal of Allergy and Clinical Immunology · 2012 · 124 citations
    2. Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin Brain Behavior and Immunity · 2004 · 115 citations
    3. A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle - dependent changes in mast cell - nerve fiber contacts in murine skin Archives of Dermatological Research · 1997 · 109 citations
    4. Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition Journal of Molecular Medicine · 2005 · 76 citations
    5. A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis International Journal of Molecular Sciences · 2020 · 35 citations
    6. Dermal fibrosis in male pattern hair loss: a suggestive implication of mast cells Archives of Dermatological Research · 2008 · 19 citations
    7. The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen‐free Lambs Following Primary and Secondary Challenge with Orf Virus Veterinary Dermatology · 1990 · 18 citations
    8. <i>Urticaria Neonatorum:</i> Accumulation of tryptase‐expressing mast cells in the skin lesions of newborns with Erythema Toxicum Pediatric allergy and immunology · 2007 · 14 citations
    9. Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth Annals of Dermatology · 2016 · 13 citations
    10. Presence of mast cells and mast cell degranulation in scalp biopsies of telogen effluvium International Journal of Trichology · 2017 · 9 citations
    11. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle The Journal of Allergy and Clinical Immunology · 2018 · 8 citations
    12. Sorafenib stimulates human skin type mast cell degranulation and maturation Journal of dermatological science · 2017 · 7 citations
    13. Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice Immunogenetics · 2008 · 7 citations
    14. Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases International journal of molecular sciences · 2023 · 6 citations
    15. A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning Journal of Cutaneous Pathology · 2013 · 6 citations
    16. SARS-CoV-2 vaccination complicated by small fiber neuropathy, mast cell activation syndrome, and pericarditis Clinics · 2023 · 4 citations
    17. Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases Experimental Dermatology · 2024 · 4 citations
    18. Mast Cells and Scarring Alopecia: Is There a Clear Pathophysiological Relationship? Actas Dermo-Sifiliográficas · 2015 · 2 citations
    19. Quantification of mast cells in central centrifugal cicatricial alopecia JAAD International · 2023 · 1 citations
    20. The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances Experimental Dermatology · 2025 · 1 citations
    21. Mast cell-5-HT-HTR2A axis involvement in chronic itch induced by SADBE Molecular Pain · 2025
    22. Mast-cell driven dermal white adipose tissue remodeling amplifies inflammation and fibrosis in atopic dermatitis 2026
    23. 865 Frontal fibrosing alopecia is associated with dysregulation of cholesterol biosynthesis pathways, fibrosis and mast cells Journal of Investigative Dermatology · 2019
    24. 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways 2019
    25. 923 Molecular phenotyping of lichen planopilaris revealed dysregulation of cholesterol/fatty acid metabolism, fibrosis and mast cell pathways Journal of Investigative Dermatology · 2019
    26. 509 Using the human iPSCs-derived sensory neurons re-innervated skin ex vivo model to investigate mast cell-nerve fiber cross-talk in solar elastosis Journal of Investigative Dermatology · 2024
    27. 1348 Involvement of mast cells and CB1 in the pathogenesis of IgA vasculitis Journal of Investigative Dermatology · 2023
    28. Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study Galen Medical Journal · 2020
    29. Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study Galen Medical Journal · 2020
    30. A case of systemic mastocytosis - an ultrastructural and immunohistochemical study of the dermal mast cells in relation to activation of the epidermal melanin unit Journal of The European Academy of Dermatology and Venereology · 1998 · 2 citations